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TTC33 tetratricopeptide repeat domain 33 [ Homo sapiens (human) ]

Gene ID: 23548, updated on 25-Nov-2025
Official Symbol
TTC33provided by HGNC
Official Full Name
tetratricopeptide repeat domain 33provided by HGNC
Primary source
HGNC:HGNC:29959
See related
Ensembl:ENSG00000113638 AllianceGenome:HGNC:29959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSRF
Expression
Ubiquitous expression in brain (RPKM 7.4), thyroid (RPKM 4.0) and 24 other tissues See more
Orthologs
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See TTC33 in Genome Data Viewer
Location:
5p13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (40711576..40755961, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (40967941..41012360, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40711678..40756063, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374737 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:40681035-40681562 Neighboring gene prostaglandin E receptor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22503 Neighboring gene PRKAA1 antisense RNA 1 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene small nucleolar RNA SNORA57

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Affinity Purification Mass Spectrometry on the Orbitrap-Astral Mass Spectrometer Enables High-Throughput Protein-Protein Interaction Mapping. Serrano LR, et al. J Proteome Res, 2025 Apr 4. PMID 40025722, Free PMC Article
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  3. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
  4. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, et al. Cell Syst, 2017 Apr 26. PMID 28330616
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis N, et al. Cell Rep, 2016 Nov 22. PMID 27880917

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
tetratricopeptide repeat protein 33
Names
TPR repeat protein 33
osmosis responsive factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012382.3 → NP_036514.1  tetratricopeptide repeat protein 33

    See identical proteins and their annotated locations for NP_036514.1

    Status: VALIDATED

    Source sequence(s)
    AC093264, AI174764, BC015701, BC036536, BE869916, BF509085, BM543635, BM689740, BQ922097, CR738110, DA518274, DA652008
    Consensus CDS
    CCDS3931.1
    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
    Related
    ENSP00000338533.4, ENST00000337702.5
    Conserved Domains (2) summary
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]
    cl27017
    Location:71 → 192
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    40711576..40755961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514003.4 → XP_011512305.1  tetratricopeptide repeat protein 33 isoform X1

    See identical proteins and their annotated locations for XP_011512305.1

    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
    Related
    ENSP00000607697.1, ENST00000937638.1
    Conserved Domains (2) summary
    sd00006
    Location:59 → 87
    TPR; TPR repeat [structural motif]
    cl27017
    Location:71 → 192
    YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    40967941..41012360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352255.1 → XP_054208230.1  tetratricopeptide repeat protein 33 isoform X1

    UniProtKB/Swiss-Prot
    B2R6G0, O95105, Q6PID6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PID6.2 GenPept UniProtKB/Swiss-Prot:Q6PID6

Gene LinkOut

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