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Coro2b coronin, actin binding protein, 2B [ Mus musculus (house mouse) ]

Gene ID: 235431, updated on 25-Jan-2022

Summary

Official Symbol
Coro2bprovided by MGI
Official Full Name
coronin, actin binding protein, 2Bprovided by MGI
Primary source
MGI:MGI:2444283
See related
Ensembl:ENSMUSG00000041729 AllianceGenome:MGI:2444283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLIPINC; E130012P22Rik
Summary
Predicted to enable actin filament binding activity; talin binding activity; and vinculin binding activity. Acts upstream of or within focal adhesion assembly; negative regulation of stress fiber assembly; and regulation of glomerular filtration. Located in focal adhesion. Is expressed in cerebral cortex; dorsal root ganglion; and hippocampus. Orthologous to human CORO2B (coronin 2B). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in cerebellum adult (RPKM 45.9), cortex adult (RPKM 26.6) and 16 other tissues See more
Orthologs
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Genomic context

See Coro2b in Genome Data Viewer
Location:
9; 9 B
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62326770..62444326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62419490..62537044, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (62267299..62384851, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40522 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523 Neighboring gene predicted gene, 39352 Neighboring gene predicted gene, 53532

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables talin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
coronin-2B
Names
E130012P22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175484.3NP_780693.2  coronin-2B

    See identical proteins and their annotated locations for NP_780693.2

    Status: VALIDATED

    Source sequence(s)
    AK087414, BB647296, BC062649
    Consensus CDS
    CCDS23264.2
    UniProtKB/Swiss-Prot
    Q8BH44
    Related
    ENSMUSP00000041826.6, ENSMUST00000048043.12
    Conserved Domains (2) summary
    sd00039
    Location:4585
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:15460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62326770..62444326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511100.4XP_006511163.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511163.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006511094.5XP_006511157.3  coronin-2B isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:65105
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:35480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_036154902.1XP_036010795.1  coronin-2B isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006511099.5XP_006511162.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511162.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006511097.5XP_006511160.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511160.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006511098.5XP_006511161.1  coronin-2B isoform X3

    See identical proteins and their annotated locations for XP_006511161.1

    UniProtKB/Swiss-Prot
    Q8BH44
    Conserved Domains (2) summary
    sd00039
    Location:4080
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10455
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006511095.3XP_006511158.1  coronin-2B isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:4383
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:13458
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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