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MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 23542, updated on 2-Mar-2021

Summary

Official Symbol
MAPK8IP2provided by HGNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:6883
See related
Ensembl:ENSG00000008735 MIM:607755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IB2; IB-2; JIP2; PRKM8IPL
Summary
This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Expression
Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues See more
Orthologs
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Genomic context

See MAPK8IP2 in Genome Data Viewer
Location:
22q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50600793..50613978)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51039222..51052406)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene CHKB-CPT1B readthrough (NMD candidate) Neighboring gene CHKB divergent transcript Neighboring gene choline kinase beta Neighboring gene arylsulfatase A Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene RNA, U6 small nuclear 409, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP-kinase scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
amyloid-beta binding NAS
Non-traceable Author Statement
more info
PubMed 
kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
JNK cascade IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
mating behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
nonassociative learning ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
signal complex assembly TAS
Traceable Author Statement
more info
PubMed 
social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 2
Names
JNK MAP kinase scaffold protein 2
JNK MAP kinase scaffold protein JIP2
JNK-interacting protein 2
homologous to mouse JIP-1
islet-brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032955.2 RefSeqGene

    Range
    5109..18294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012324.6NP_036456.1  C-Jun-amino-terminal kinase-interacting protein 2

    See identical proteins and their annotated locations for NP_036456.1

    Status: REVIEWED

    Source sequence(s)
    AF136382, AI066766, AK094442, U62317
    Consensus CDS
    CCDS74886.1
    UniProtKB/Swiss-Prot
    Q13387
    Related
    ENSP00000330572.4, ENST00000329492.6
    Conserved Domains (2) summary
    cd11942
    Location:608662
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:679824
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50600793..50613978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530679.2XP_011528981.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    cd11942
    Location:609663
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:680825
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
  2. XM_011530680.2XP_011528982.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    cd11942
    Location:571625
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:642787
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
  3. XM_011530681.2XP_011528983.1  C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

    Conserved Domains (2) summary
    cd11942
    Location:564618
    SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
    cd01212
    Location:635780
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016431.3: Suppressed sequence

    Description
    NM_016431.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_139124.1: Suppressed sequence

    Description
    NM_139124.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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