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Cplx3 complexin 3 [ Mus musculus (house mouse) ]

Gene ID: 235415, updated on 12-May-2024

Summary

Official Symbol
Cplx3provided by MGI
Official Full Name
complexin 3provided by MGI
Primary source
MGI:MGI:2384571
See related
Ensembl:ENSMUSG00000039714 AllianceGenome:MGI:2384571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERGL; CpxIII; Lamn1l; Lman1l; ERGIC-53L
Summary
Enables SNARE binding activity and neurotransmitter transmembrane transporter activity. Involved in insulin secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in cytosol; photoreceptor ribbon synapse; and plasma membrane. Is anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane. Is expressed in cerebral cortex and cortical layer V. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 6.6) and frontal lobe adult (RPKM 2.8) See more
Orthologs
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Genomic context

See Cplx3 in Genome Data Viewer
Location:
9 B; 9 31.11 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57507275..57513564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57599992..57606281, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51-like kinase 3 Neighboring gene predicted gene, 32392 Neighboring gene lectin, mannose-binding 1 like Neighboring gene c-src tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E9763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57498764-57498965

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC21420, MGC38804

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables neurotransmitter transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor ribbon synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
complexin-3
Names
CPX III
complexin III
lectin, mannose-binding, 1 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146223.3NP_666335.1  complexin-3

    See identical proteins and their annotated locations for NP_666335.1

    Status: VALIDATED

    Source sequence(s)
    AC122528, BC033343
    Consensus CDS
    CCDS23226.1
    UniProtKB/Swiss-Prot
    Q8R1B5, Q96AW7
    Related
    ENSMUSP00000046748.9, ENSMUST00000045068.10
    Conserved Domains (1) summary
    pfam05835
    Location:1139
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57507275..57513564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)