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FOSB FosB proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 2354, updated on 10-May-2020

Summary

Official Symbol
FOSBprovided by HGNC
Official Full Name
FosB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:3797
See related
Ensembl:ENSG00000125740 MIM:164772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-1; G0S3; GOS3; GOSB
Summary
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues See more
Orthologs

Genomic context

See FOSB in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45467996..45475179)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45971253..45978437)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 13779 Neighboring gene microRNA 6088 Neighboring gene reticulon 2 Neighboring gene uncharacterized LOC107985314 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42291, DKFZp686C0818

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein fosB
Names
FBJ murine osteosarcoma viral oncogene homolog B
FosB proto-oncogene, AP-1 trancription factor subunit
G0/G1 switch regulatory protein 3
activator protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029675.1 RefSeqGene

    Range
    5002..12185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001114171.2NP_001107643.1  protein fosB isoform 2

    See identical proteins and their annotated locations for NP_001107643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an inframe coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC138128, DA589470, DB275824, EU178109
    Consensus CDS
    CCDS46113.1
    UniProtKB/Swiss-Prot
    P53539
    Related
    ENSP00000407207.1, ENST00000417353.6
    Conserved Domains (1) summary
    cl21462
    Location:150182
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. NM_006732.3NP_006723.2  protein fosB isoform 1

    See identical proteins and their annotated locations for NP_006723.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC138128, BC036724, DA589470, DB275824
    Consensus CDS
    CCDS12664.1
    UniProtKB/Swiss-Prot
    P53539
    UniProtKB/TrEMBL
    A0A024R0P6
    Related
    ENSP00000245919.3, ENST00000353609.8
    Conserved Domains (1) summary
    cd14721
    Location:165218
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45467996..45475179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258691.1XP_005258748.1  protein fosB isoform X1

    UniProtKB/TrEMBL
    K7EKC1
    Related
    ENSP00000465552.1, ENST00000592436.5
    Conserved Domains (1) summary
    cd14721
    Location:165218
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
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