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SLC16A8 solute carrier family 16 member 8 [ Homo sapiens (human) ]

Gene ID: 23539, updated on 22-Sep-2022

Summary

Official Symbol
SLC16A8provided by HGNC
Official Full Name
solute carrier family 16 member 8provided by HGNC
Primary source
HGNC:HGNC:16270
See related
Ensembl:ENSG00000100156 MIM:610409; AllianceGenome:HGNC:16270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT3; REMP
Summary
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Expression
Broad expression in prostate (RPKM 2.1), testis (RPKM 0.9) and 20 other tissues See more
Orthologs
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Genomic context

See SLC16A8 in Genome Data Viewer
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38078137..38084184, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38539763..38545772, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38474144..38480191, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs492 Neighboring gene protein interacting with PRKCA 1 Neighboring gene uncharacterized LOC105373027 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene phospholipase A2 group VI Neighboring gene Sharpr-MPRA regulatory region 6169

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lactate transport TAS
Traceable Author Statement
more info
PubMed 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
monocarboxylate transporter 3
Names
MCT 3
solute carrier 16 (monocarboxylic acid transporters), member 8
solute carrier family 16 (monocarboxylate transporter), member 8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394131.1NP_001381060.1  monocarboxylate transporter 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL031587
    Related
    ENST00000469516.5
    Conserved Domains (1) summary
    TIGR00892
    Location:134
    2A0113; monocarboxylate transporter 1
  2. NM_013356.3NP_037488.2  monocarboxylate transporter 3 isoform 1

    See identical proteins and their annotated locations for NP_037488.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031587
    Consensus CDS
    CCDS13966.1
    UniProtKB/Swiss-Prot
    O95907, Q9UBE2
    Related
    ENSP00000506669.1, ENST00000681075.2
    Conserved Domains (2) summary
    cd06174
    Location:19429
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1460
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38078137..38084184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028685.2XP_016884174.1  monocarboxylate transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    O95907, Q9UBE2
    Conserved Domains (2) summary
    cd06174
    Location:19429
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1460
    2A0113; monocarboxylate transporter 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38539763..38545772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)