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PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 [ Homo sapiens (human) ]

Gene ID: 23533, updated on 1-Jun-2020

Summary

Official Symbol
PIK3R5provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 5provided by HGNC
Primary source
HGNC:HGNC:30035
See related
Ensembl:ENSG00000141506 MIM:611317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p101; FOAP-2; P101-PI3K; F730038I15Rik
Summary
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Expression
Biased expression in bone marrow (RPKM 25.8), spleen (RPKM 14.1) and 13 other tissues See more
Orthologs

Genomic context

See PIK3R5 in Genome Data Viewer
Location:
17p13.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8878916..8965712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8782233..8869029, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 6 like Neighboring gene phosphoinositide-3-kinase regulatory subunit 6 Neighboring gene uncharacterized LOC107985071 Neighboring gene uncharacterized LOC107985063 Neighboring gene uncharacterized CTB-41I6.1 Neighboring gene netrin 1 Neighboring gene uncharacterized LOC101928266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class IB ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 5
Names
PI3-kinase p101 subunit
phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
protein FOAP-2
ptdIns-3-kinase p101

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030374.1 RefSeqGene

    Range
    5001..91797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142633.2NP_001136105.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_001136105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein (isoform 1).
    Source sequence(s)
    AB028925, AK309074, AY725854, BC028212
    Consensus CDS
    CCDS11147.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    UniProtKB/TrEMBL
    L7RT34
    Related
    ENSP00000392812.1, ENST00000447110.5
    Conserved Domains (1) summary
    pfam10486
    Location:6880
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. NM_001251851.2NP_001238780.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in an internal region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 3-6 encode the same isoform 2.
    Source sequence(s)
    AF128881, AK309074, AY725851, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  3. NM_001251852.1NP_001238781.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238781.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 3-6 encode the same isoform 2.
    Source sequence(s)
    AF128881, AK309074, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000484211.1, ENST00000616147.4
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  4. NM_001251853.1NP_001238782.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in an internal region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 3-6 encode the same isoform 2.
    Source sequence(s)
    AB028925, AF128881, AK309074, AY725852, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000477795.1, ENST00000611902.4
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  5. NM_001251855.1NP_001238784.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238784.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in an internal region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus than isoform 1. Variants 3-6 encode the same isoform 2.
    Source sequence(s)
    AF128881, AK309074, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000485280.1, ENST00000623421.3
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  6. NM_014308.3NP_055123.2  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_055123.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR exon, compared to variant 1. Both variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AF128881, BC028212
    Consensus CDS
    CCDS11147.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    UniProtKB/TrEMBL
    L7RT34
    Related
    ENSP00000462433.1, ENST00000581552.5
    Conserved Domains (1) summary
    pfam10486
    Location:6880
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8878916..8965712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256580.3XP_005256637.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/TrEMBL
    J3KSW1
    Related
    ENSP00000462680.1, ENST00000584803.1
    Conserved Domains (1) summary
    pfam10486
    Location:6879
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
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