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PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 [ Homo sapiens (human) ]

Gene ID: 23533, updated on 7-Sep-2023

Summary

Official Symbol
PIK3R5provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 5provided by HGNC
Primary source
HGNC:HGNC:30035
See related
Ensembl:ENSG00000141506 MIM:611317; AllianceGenome:HGNC:30035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p101; FOAP-2; P101-PI3K; F730038I15Rik
Summary
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]
Expression
Biased expression in bone marrow (RPKM 25.8), spleen (RPKM 14.1) and 13 other tissues See more
Orthologs
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Genomic context

See PIK3R5 in Genome Data Viewer
Location:
17p13.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8878916..8965707, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8786072..8872872, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8782233..8869024, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8730902-8731702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8731703-8732503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8740143-8740949 Neighboring gene phosphoinositide-3-kinase regulatory subunit 6 Neighboring gene uncharacterized LOC107985071 Neighboring gene uncharacterized LOC124903919 Neighboring gene uncharacterized LOC124903922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8791248-8792056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8792057-8792865 Neighboring gene uncharacterized LOC124903920 Neighboring gene uncharacterized LOC124903921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8857999-8858500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8858501-8859000 Neighboring gene PIK3R5 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8907139-8907768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8924225-8924768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8936035-8936534 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:8954033-8954690 and GRCh37_chr17:8954691-8955350 Neighboring gene netrin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8955351-8956008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8956741-8957362 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8957363-8957982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8957983-8958603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8990973-8991474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8991475-8991974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9041579-9042287 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:9054043-9054886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9058975-9059476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:9059477-9059976 Neighboring gene uncharacterized LOC101928266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ26116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein beta/gamma-subunit complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA EXP
Inferred from Experiment
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 5
Names
PI3-kinase p101 subunit
phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
protein FOAP-2
ptdIns-3-kinase p101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030374.1 RefSeqGene

    Range
    5006..91797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142633.3NP_001136105.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_001136105.1

    Status: REVIEWED

    Source sequence(s)
    AB028925, AK309074, AY725854, BC028212
    Consensus CDS
    CCDS11147.1
    UniProtKB/Swiss-Prot
    B0LPH4, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q8WYR1, Q9Y2Y2
    UniProtKB/TrEMBL
    L7RT34
    Related
    ENSP00000392812.1, ENST00000447110.6
    Conserved Domains (1) summary
    pfam10486
    Location:6880
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. NM_001251851.2NP_001238780.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238780.1

    Status: REVIEWED

    Source sequence(s)
    AF128881, AK309074, AY725851, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  3. NM_001251852.2NP_001238781.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238781.1

    Status: REVIEWED

    Source sequence(s)
    AF128881, AK309074, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000484211.1, ENST00000616147.4
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  4. NM_001251853.2NP_001238782.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238782.1

    Status: REVIEWED

    Source sequence(s)
    AB028925, AF128881, AK309074, AY725852, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000477795.1, ENST00000611902.4
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  5. NM_001251855.2NP_001238784.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_001238784.1

    Status: REVIEWED

    Source sequence(s)
    AF128881, AK309074, BC028212
    Consensus CDS
    CCDS73986.1
    UniProtKB/Swiss-Prot
    Q8WYR1
    Related
    ENSP00000485280.1, ENST00000623421.3
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  6. NM_001388396.1NP_001375325.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC002091, AC003695
    Consensus CDS
    CCDS92257.1
    UniProtKB/TrEMBL
    J3KSW1
    Related
    ENSP00000462680.1, ENST00000584803.1
    Conserved Domains (1) summary
    pfam10486
    Location:6879
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  7. NM_001388397.1NP_001375326.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002091, AC003695
    Consensus CDS
    CCDS73986.1
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  8. NM_001388398.1NP_001375327.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002091, AC003695
    Consensus CDS
    CCDS73986.1
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  9. NM_001388399.1NP_001375328.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002091, AC003695
    Consensus CDS
    CCDS73986.1
    Conserved Domains (1) summary
    pfam10486
    Location:1494
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  10. NM_001388400.1NP_001375329.1  phosphoinositide 3-kinase regulatory subunit 5 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002091, AC003695
    Conserved Domains (1) summary
    pfam10486
    Location:1493
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  11. NM_014308.4NP_055123.2  phosphoinositide 3-kinase regulatory subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_055123.2

    Status: REVIEWED

    Source sequence(s)
    AF128881, BC028212
    Consensus CDS
    CCDS11147.1
    UniProtKB/Swiss-Prot
    B0LPH4, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q8WYR1, Q9Y2Y2
    UniProtKB/TrEMBL
    L7RT34
    Related
    ENSP00000462433.1, ENST00000581552.5
    Conserved Domains (1) summary
    pfam10486
    Location:6880
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8878916..8965707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435709.1XP_047291665.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/Swiss-Prot
    B0LPH4, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q8WYR1, Q9Y2Y2
    UniProtKB/TrEMBL
    L7RT34
  2. XM_047435711.1XP_047291667.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X3

  3. XM_047435710.1XP_047291666.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8786072..8872872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315631.1XP_054171606.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

    UniProtKB/Swiss-Prot
    B0LPH4, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q8WYR1, Q9Y2Y2
    UniProtKB/TrEMBL
    L7RT34
  2. XM_054315633.1XP_054171608.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X3

  3. XM_054315632.1XP_054171607.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X2