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Scn3b sodium channel, voltage-gated, type III, beta [ Mus musculus (house mouse) ]

Gene ID: 235281, updated on 9-May-2024

Summary

Official Symbol
Scn3bprovided by MGI
Official Full Name
sodium channel, voltage-gated, type III, betaprovided by MGI
Primary source
MGI:MGI:1918882
See related
Ensembl:ENSMUSG00000049281 AllianceGenome:MGI:1918882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scnb3; 1110001K16Rik; 4833414B02Rik
Summary
Enables transmembrane transporter binding activity and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upstream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 43.1), whole brain E14.5 (RPKM 26.9) and 7 other tissues See more
Orthologs
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Genomic context

See Scn3b in Genome Data Viewer
Location:
9 A5.1; 9 21.42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40180512..40202914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40269216..40291618)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene zinc finger protein 202 Neighboring gene STARR-seq mESC enhancer starr_23849 Neighboring gene STARR-seq mESC enhancer starr_23851 Neighboring gene GRAM domain containing 1B Neighboring gene RIKEN cDNA 1700110K17 gene Neighboring gene STARR-seq mESC enhancer starr_23853 Neighboring gene STARR-seq mESC enhancer starr_23854 Neighboring gene STARR-positive B cell enhancer mm9_chr9:40222671-40222972 Neighboring gene predicted gene, 51668

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SA node cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell action potential involved in contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated sodium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium channel regulatory subunit beta-3
Names
brain and heart sodium channel beta 3 subunit
sodium channel subunit beta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083917.1NP_001077386.1  sodium channel regulatory subunit beta-3 isoform a precursor

    See identical proteins and their annotated locations for NP_001077386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 2. Variants 2, 3 and 5 encode the same protein (isoform a).
    Source sequence(s)
    BC053919, CB520894
    Consensus CDS
    CCDS23080.1
    UniProtKB/Swiss-Prot
    Q8BHK2, Q91Z99
    UniProtKB/TrEMBL
    Q0P666, Q69ZQ3
    Related
    ENSMUSP00000051627.6, ENSMUST00000049941.12
    Conserved Domains (1) summary
    pfam07686
    Location:28122
    V-set; Immunoglobulin V-set domain
  2. NM_001286614.1NP_001273543.1  sodium channel regulatory subunit beta-3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' splice site, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform b, which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    BC058083, BC058636, CB520894
    Consensus CDS
    CCDS72214.1
    UniProtKB/TrEMBL
    H3BJR6
    Related
    ENSMUSP00000135096.2, ENSMUST00000176185.8
    Conserved Domains (2) summary
    pfam07686
    Location:282
    V-set; Immunoglobulin V-set domain
    cd00096
    Location:3338
    Ig; Ig strand C' [structural motif]
  3. NM_001359700.1NP_001346629.1  sodium channel regulatory subunit beta-3 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR, compared to variant 2. Variants 2, 3 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AC135353, BC058636
    Consensus CDS
    CCDS23080.1
    UniProtKB/Swiss-Prot
    Q8BHK2, Q91Z99
    UniProtKB/TrEMBL
    Q0P666, Q69ZQ3
    Conserved Domains (1) summary
    pfam07686
    Location:28122
    V-set; Immunoglobulin V-set domain
  4. NM_178227.4NP_839941.1  sodium channel regulatory subunit beta-3 isoform a precursor

    See identical proteins and their annotated locations for NP_839941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 2, 3 and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK049747, BC053919, CB520894
    Consensus CDS
    CCDS23080.1
    UniProtKB/Swiss-Prot
    Q8BHK2, Q91Z99
    UniProtKB/TrEMBL
    Q0P666, Q69ZQ3
    Related
    ENSMUSP00000132933.3, ENSMUST00000171835.9
    Conserved Domains (1) summary
    pfam07686
    Location:28122
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    40180512..40202914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153522.2: Suppressed sequence

    Description
    NM_153522.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.