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ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Homo sapiens (human) ]

Gene ID: 23527, updated on 17-Jun-2019

Summary

Official Symbol
ACAP2provided by HGNC
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by HGNC
Primary source
HGNC:HGNC:16469
See related
Ensembl:ENSG00000114331 MIM:607766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENTB2; CNT-B2
Expression
Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See ACAP2 in Genome Data Viewer
Location:
3q29
Exon count:
29
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195274742..195443176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194995465..195163817, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene uncharacterized LOC105374296 Neighboring gene XXYLT1 antisense RNA 2 Neighboring gene RNA, U6 small nuclear 25, pseudogene Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene RNA, U6atac small nuclear 24, pseudogene Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to nerve growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Names
Arf GAP with coiled coil, ANK repeat and PH domains 2
centaurin-beta-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012287.6NP_036419.3  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_036419.3

    Status: VALIDATED

    Source sequence(s)
    AC090018, BC017120, CA413842, D26069, DB087306
    Consensus CDS
    CCDS33924.1
    UniProtKB/Swiss-Prot
    Q15057
    Related
    ENSP00000324287.6, ENST00000326793.11
    Conserved Domains (5) summary
    cd07638
    Location:18217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:402517
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:610726
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:638671
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    195274742..195443176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006046.1XP_016861535.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

  2. XM_017006049.1XP_016861538.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

  3. XM_017006048.1XP_016861537.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

  4. XM_006713557.3XP_006713620.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_006713620.1

    Conserved Domains (7) summary
    cd07638
    Location:18217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:409524
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:617733
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267368
    PH; PH domain
    pfam12796
    Location:617711
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:645678
    ANK; ANK repeat [structural motif]
  5. XM_011512604.2XP_011510906.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    See identical proteins and their annotated locations for XP_011510906.1

    Conserved Domains (7) summary
    smart00105
    Location:365480
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:608724
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:225328
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:223324
    PH; PH domain
    pfam12796
    Location:608702
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:636669
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1173
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_017006047.1XP_016861536.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

  7. XM_011512603.2XP_011510905.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011510905.1

    Related
    ENSP00000484209.1, ENST00000618471.4
    Conserved Domains (8) summary
    cd07638
    Location:18217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:402517
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:387631
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd00204
    Location:645761
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267361
    PH; PH domain
    pfam12796
    Location:645739
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:673706
    ANK; ANK repeat [structural motif]
  8. XM_011512602.2XP_011510904.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011510904.1

    Conserved Domains (8) summary
    cd07638
    Location:18217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:409524
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    COG5347
    Location:394638
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd00204
    Location:652768
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267368
    PH; PH domain
    pfam12796
    Location:652746
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:680713
    ANK; ANK repeat [structural motif]
  9. XM_011512606.2XP_011510908.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    See identical proteins and their annotated locations for XP_011510908.1

    Conserved Domains (7) summary
    smart00105
    Location:365480
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:608724
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:225328
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:223324
    PH; PH domain
    pfam12796
    Location:608702
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:636669
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1173
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  10. XM_011512605.2XP_011510907.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    See identical proteins and their annotated locations for XP_011510907.1

    Conserved Domains (7) summary
    smart00105
    Location:365480
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:608724
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:225328
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:223324
    PH; PH domain
    pfam12796
    Location:608702
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:636669
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1173
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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