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CABIN1 calcineurin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23523, updated on 13-May-2022

Summary

Official Symbol
CABIN1provided by HGNC
Official Full Name
calcineurin binding protein 1provided by HGNC
Primary source
HGNC:HGNC:24187
See related
Ensembl:ENSG00000099991 MIM:604251; AllianceGenome:HGNC:24187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAIN; PPP3IN; KB-318B8.7
Summary
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CABIN1 in Genome Data Viewer
Location:
22q11.23
Exon count:
40
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (24011304..24178628)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24472930..24640242)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24407754..24574596)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372959 Neighboring gene glutathione S-transferase theta 4 Neighboring gene Sharpr-MPRA regulatory region 1007 Neighboring gene skeletal muscle cis-regulatory module in CABIN1 intron Neighboring gene sushi domain containing 2 Neighboring gene uncharacterized LOC124905090

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcineurin-binding protein cabin-1
Names
calcineurin binding protein cabin 1
calcineurin inhibitor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047136.1 RefSeqGene

    Range
    5113..172437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199281.1NP_001186210.1  calcineurin-binding protein cabin-1 isoform a

    See identical proteins and their annotated locations for NP_001186210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AB002328, AL703593
    Consensus CDS
    CCDS13823.1
    UniProtKB/Swiss-Prot
    Q9Y6J0
    UniProtKB/TrEMBL
    A0A024R1E5
    Related
    ENSP00000381364.2, ENST00000398319.6
    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21562190
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19452030
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:20022130
    RelB_transactiv; RelB transactivation domain
  2. NM_001201429.2NP_001188358.1  calcineurin-binding protein cabin-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB002328, AC253536, AF072441, BC054497
    Consensus CDS
    CCDS74830.1
    UniProtKB/Swiss-Prot
    Q9Y6J0
    UniProtKB/TrEMBL
    A0A087WWW8
    Related
    ENSP00000480560.1, ENST00000617531.4
    Conserved Domains (4) summary
    COG0457
    Location:34210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21062140
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    cl26464
    Location:18642107
    Atrophin-1; Atrophin-1 family
  3. NM_012295.4NP_036427.1  calcineurin-binding protein cabin-1 isoform a

    See identical proteins and their annotated locations for NP_036427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC253536, AF072441
    Consensus CDS
    CCDS13823.1
    UniProtKB/Swiss-Prot
    Q9Y6J0
    UniProtKB/TrEMBL
    A0A024R1E5
    Related
    ENSP00000263119.5, ENST00000263119.10
    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21562190
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19452030
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:20022130
    RelB_transactiv; RelB transactivation domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    24011304..24178628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441218.1XP_047297174.1  calcineurin-binding protein cabin-1 isoform X4

  2. XM_047441219.1XP_047297175.1  calcineurin-binding protein cabin-1 isoform X6

  3. XM_047441226.1XP_047297182.1  calcineurin-binding protein cabin-1 isoform X12

  4. XM_047441232.1XP_047297188.1  calcineurin-binding protein cabin-1 isoform X15

  5. XM_024452184.2XP_024307952.1  calcineurin-binding protein cabin-1 isoform X1

    Conserved Domains (4) summary
    COG0457
    Location:34210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21912225
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    cl26464
    Location:19492192
    Atrophin-1; Atrophin-1 family
  6. XM_047441217.1XP_047297173.1  calcineurin-binding protein cabin-1 isoform X4

  7. XM_047441221.1XP_047297177.1  calcineurin-binding protein cabin-1 isoform X9

  8. XM_047441224.1XP_047297180.1  calcineurin-binding protein cabin-1 isoform X12

  9. XM_047441222.1XP_047297178.1  calcineurin-binding protein cabin-1 isoform X10

  10. XM_047441225.1XP_047297181.1  calcineurin-binding protein cabin-1 isoform X11

  11. XM_047441236.1XP_047297192.1  calcineurin-binding protein cabin-1 isoform X19

  12. XM_047441227.1XP_047297183.1  calcineurin-binding protein cabin-1 isoform X13

  13. XM_047441238.1XP_047297194.1  calcineurin-binding protein cabin-1 isoform X20

  14. XM_047441240.1XP_047297196.1  calcineurin-binding protein cabin-1 isoform X21

  15. XM_047441220.1XP_047297176.1  calcineurin-binding protein cabin-1 isoform X8

  16. XM_047441234.1XP_047297190.1  calcineurin-binding protein cabin-1 isoform X16

  17. XM_005261419.3XP_005261476.1  calcineurin-binding protein cabin-1 isoform X7

    Conserved Domains (4) summary
    COG0457
    Location:14165
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21462180
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:3664
    TPR; TPR repeat [structural motif]
    cl26464
    Location:19042147
    Atrophin-1; Atrophin-1 family
  18. XM_047441229.1XP_047297185.1  calcineurin-binding protein cabin-1 isoform X14

  19. XM_047441231.1XP_047297187.1  calcineurin-binding protein cabin-1 isoform X15

  20. XM_047441244.1XP_047297200.1  calcineurin-binding protein cabin-1 isoform X23

  21. XM_047441243.1XP_047297199.1  calcineurin-binding protein cabin-1 isoform X22

  22. XM_047441246.1XP_047297202.1  calcineurin-binding protein cabin-1 isoform X26

  23. XM_047441249.1XP_047297205.1  calcineurin-binding protein cabin-1 isoform X29

  24. XM_005261415.4XP_005261472.1  calcineurin-binding protein cabin-1 isoform X1

    Conserved Domains (4) summary
    COG0457
    Location:34210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21912225
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    cl26464
    Location:19492192
    Atrophin-1; Atrophin-1 family
  25. XM_006724179.3XP_006724242.1  calcineurin-binding protein cabin-1 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:19482200
    PHA03247; large tegument protein UL36; Provisional
    COG0457
    Location:34210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21622196
    MEF2_binding; MEF2 binding
  26. XM_005261416.4XP_005261473.1  calcineurin-binding protein cabin-1 isoform X2

    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21862220
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19752060
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:20322160
    RelB_transactiv; RelB transactivation domain
  27. XM_017028680.3XP_016884169.1  calcineurin-binding protein cabin-1 isoform X5

  28. XM_005261417.4XP_005261474.1  calcineurin-binding protein cabin-1 isoform X4

    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21612195
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19502035
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:20072135
    RelB_transactiv; RelB transactivation domain
  29. XM_006724181.3XP_006724244.1  calcineurin-binding protein cabin-1 isoform X12

    Conserved Domains (5) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21272161
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    cl21589
    Location:19092098
    Relaxase; Relaxase/Mobilization nuclease domain
  30. XM_006724180.3XP_006724243.1  calcineurin-binding protein cabin-1 isoform X10

    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21322166
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19212006
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:19782106
    RelB_transactiv; RelB transactivation domain
  31. XM_047441223.1XP_047297179.1  calcineurin-binding protein cabin-1 isoform X11

  32. XM_011530026.3XP_011528328.1  calcineurin-binding protein cabin-1 isoform X13

    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:21262160
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:19152000
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:19722100
    RelB_transactiv; RelB transactivation domain
  33. XM_047441237.1XP_047297193.1  calcineurin-binding protein cabin-1 isoform X20

  34. XM_047441239.1XP_047297195.1  calcineurin-binding protein cabin-1 isoform X21

  35. XM_017028681.3XP_016884170.1  calcineurin-binding protein cabin-1 isoform X8

  36. XM_047441235.1XP_047297191.1  calcineurin-binding protein cabin-1 isoform X17

  37. XM_047441233.1XP_047297189.1  calcineurin-binding protein cabin-1 isoform X16

  38. XM_024452187.2XP_024307955.1  calcineurin-binding protein cabin-1 isoform X18

    Conserved Domains (4) summary
    COG0457
    Location:34210
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21062140
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    cl26464
    Location:18642107
    Atrophin-1; Atrophin-1 family
  39. XM_047441245.1XP_047297201.1  calcineurin-binding protein cabin-1 isoform X25

  40. XM_017028683.3XP_016884172.1  calcineurin-binding protein cabin-1 isoform X24

    UniProtKB/Swiss-Prot
    Q9Y6J0
    Related
    ENSP00000384694.2, ENST00000405822.6
    Conserved Domains (6) summary
    sd00006
    Location:90118
    TPR; TPR repeat [structural motif]
    pfam09047
    Location:20772111
    MEF2_binding; MEF2 binding
    pfam13414
    Location:92155
    TPR_11; TPR repeat
    pfam13424
    Location:36120
    TPR_12; Tetratricopeptide repeat
    pfam15444
    Location:18661951
    TMEM247; Transmembrane protein 247
    pfam16181
    Location:19232051
    RelB_transactiv; RelB transactivation domain
  41. XM_024452186.2XP_024307954.1  calcineurin-binding protein cabin-1 isoform X7

    Conserved Domains (4) summary
    COG0457
    Location:14165
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13839
    Location:21462180
    MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
    sd00006
    Location:3664
    TPR; TPR repeat [structural motif]
    cl26464
    Location:19042147
    Atrophin-1; Atrophin-1 family
  42. XM_047441228.1XP_047297184.1  calcineurin-binding protein cabin-1 isoform X14

  43. XM_047441230.1XP_047297186.1  calcineurin-binding protein cabin-1 isoform X15

  44. XM_047441242.1XP_047297198.1  calcineurin-binding protein cabin-1 isoform X23

  45. XM_047441241.1XP_047297197.1  calcineurin-binding protein cabin-1 isoform X22

  46. XM_047441247.1XP_047297203.1  calcineurin-binding protein cabin-1 isoform X27

  47. XM_047441248.1XP_047297204.1  calcineurin-binding protein cabin-1 isoform X28

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    301995..302395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24472930..24640242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)