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RPL13A ribosomal protein L13a [ Homo sapiens (human) ]

Gene ID: 23521, updated on 1-Aug-2020

Summary

Official Symbol
RPL13Aprovided by HGNC
Official Full Name
ribosomal protein L13aprovided by HGNC
Primary source
HGNC:HGNC:10304
See related
Ensembl:ENSG00000142541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L13A; TSTA1
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 1600.3), lymph node (RPKM 1020.4) and 25 other tissues See more
Orthologs

Genomic context

See RPL13A in Genome Data Viewer
Location:
19q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49487554..49492308)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49990811..49995565)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 16 family member A1 Neighboring gene fms related receptor tyrosine kinase 3 ligand Neighboring gene small nucleolar RNA, C/D box 32A Neighboring gene small nucleolar RNA, C/D box 35A Neighboring gene small nucleolar RNA, C/D box 33 Neighboring gene small nucleolar RNA, C/D box 34 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene ribosomal protein S11 Neighboring gene microRNA 150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
GAIT complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm HDA PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion HDA PubMed 
large ribosomal subunit TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nucleolus HDA PubMed 
nucleus HDA PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L13a
Names
23 kDa highly basic protein
epididymis secretory sperm binding protein
large ribosomal subunit protein uL13
tissue specific transplantation antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270491.1NP_001257420.1  60S ribosomal protein L13a isoform 2

    See identical proteins and their annotated locations for NP_001257420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010619, BC062537, BQ069994
    Consensus CDS
    CCDS74421.1
    UniProtKB/Swiss-Prot
    P40429
    UniProtKB/TrEMBL
    Q8J015
    Related
    ENSP00000477755.1, ENST00000621674.4
    Conserved Domains (1) summary
    cl00333
    Location:1139
    Ribosomal_L13; Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the ...
  2. NM_012423.4NP_036555.1  60S ribosomal protein L13a isoform 1

    See identical proteins and their annotated locations for NP_036555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK291120, BC062537
    Consensus CDS
    CCDS12768.1
    UniProtKB/Swiss-Prot
    P40429
    Related
    ENSP00000375730.4, ENST00000391857.9
    Conserved Domains (1) summary
    PTZ00068
    Location:6200
    PTZ00068; 60S ribosomal protein L13a; Provisional

RNA

  1. NR_073024.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB082924, AC010619, BC062537, BC105605
    Related
    ENST00000624069.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49487554..49492308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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