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Foxred1 FAD-dependent oxidoreductase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 235169, updated on 26-Sep-2022

Summary

Official Symbol
Foxred1provided by MGI
Official Full Name
FAD-dependent oxidoreductase domain containing 1provided by MGI
Primary source
MGI:MGI:2446262
See related
Ensembl:ENSMUSG00000039048 AllianceGenome:MGI:2446262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex23; TEG-23
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 17.5), subcutaneous fat pad adult (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Foxred1 in Genome Data Viewer
Location:
9 A4; 9
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35115504..35122359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35204208..35211171, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene decapping enzyme, scavenger Neighboring gene predicted gene, 24262 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene family with sequence similarity 118, member B Neighboring gene signal recognition particle receptor ('docking protein') Neighboring gene RNA pseudouridylate synthase domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC38853

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FAD-dependent oxidoreductase domain-containing protein 1
Names
testis expressed gene 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291448.1NP_001278377.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001278377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 2.
    Source sequence(s)
    AC140448, AK163722
    Consensus CDS
    CCDS80974.1
    UniProtKB/Swiss-Prot
    Q3TQB2, Q8R1D0
    Related
    ENSMUSP00000118037.2, ENSMUST00000127996.8
    Conserved Domains (2) summary
    COG0665
    Location:60479
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    cl21454
    Location:6598
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001291449.1NP_001278378.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC140448, BC017604
    Conserved Domains (1) summary
    COG0665
    Location:3302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  3. NM_001359815.1NP_001346744.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC140448
    Conserved Domains (1) summary
    COG0665
    Location:3302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  4. NM_172291.2NP_758495.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_758495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC140448, AK144759
    Consensus CDS
    CCDS22958.1
    UniProtKB/Swiss-Prot
    Q3TQB2
    Related
    ENSMUSP00000038924.9, ENSMUST00000043805.15
    Conserved Domains (2) summary
    COG0665
    Location:60485
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    cl21454
    Location:6598
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35115504..35122359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244290.2XP_030100150.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  2. XM_030244287.2XP_030100147.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    COG0665
    Location:3302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  3. XM_011242483.4XP_011240785.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011240785.1

    Conserved Domains (1) summary
    COG0665
    Location:3308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  4. XM_017313309.3XP_017168798.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    COG0665
    Location:60404
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  5. XM_006510223.5XP_006510286.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    COG0665
    Location:60410
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  6. XM_030244288.2XP_030100148.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  7. XM_006510226.5XP_006510289.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    COG0665
    Location:1297
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  8. XM_036154879.1XP_036010772.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Related
    ENSMUST00000130072.8
    Conserved Domains (1) summary
    COG0665
    Location:1291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  9. XM_030244291.2XP_030100151.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  10. XM_036154873.1XP_036010766.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  11. XM_036154874.1XP_036010767.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  12. XM_030244289.2XP_030100149.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  13. XM_006510224.5XP_006510287.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006510287.1

    Conserved Domains (1) summary
    COG0665
    Location:3308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  14. XM_036154876.1XP_036010769.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    COG0665
    Location:3302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  15. XM_036154875.1XP_036010768.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    COG0665
    Location:3302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  16. XM_036154872.1XP_036010765.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
  17. XM_036154877.1XP_036010770.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

    Related
    ENSMUST00000143039.8
    Conserved Domains (1) summary
    COG0665
    Location:1297
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

RNA

  1. XR_004935399.1 RNA Sequence

  2. XR_379111.5 RNA Sequence

    Related
    ENSMUST00000151658.8
  3. XR_004935398.1 RNA Sequence

  4. XR_003947868.2 RNA Sequence

  5. XR_379114.5 RNA Sequence

  6. XR_379113.5 RNA Sequence