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MORC3 MORC family CW-type zinc finger 3 [ Homo sapiens (human) ]

Gene ID: 23515, updated on 5-Apr-2020

Summary

Official Symbol
MORC3provided by HGNC
Official Full Name
MORC family CW-type zinc finger 3provided by HGNC
Primary source
HGNC:HGNC:23572
See related
Ensembl:ENSG00000159256 MIM:610078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NXP2; ZCW5; ZCWCC3
Summary
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See MORC3 in Genome Data Viewer
Location:
21q22.12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (36320189..36376646)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37692360..37749999)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 9 pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 1 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene ATP synthase membrane subunit f pseudogene 1 Neighboring gene uncharacterized LOC105369301 Neighboring gene claudin 14 Neighboring gene proteasome 26S subunit, non-ATPase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell aging IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MORC family CW-type zinc finger protein 3
Names
nuclear matrix protein 2
nuclear matrix protein NXP2
zinc finger CW-type coiled-coil domain protein 3
zinc finger, CW type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320445.1NP_001307374.1  MORC family CW-type zinc finger protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AK295133, BC144116, BM786077, DA434361
    UniProtKB/TrEMBL
    B4DHJ4
    Related
    ENST00000487909.5
    Conserved Domains (3) summary
    pfam07496
    Location:338375
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:698790
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:156
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  2. NM_001320446.1NP_001307375.1  MORC family CW-type zinc finger protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    BC144116, BM786077, DA434361
    UniProtKB/TrEMBL
    B4DHJ4
    Conserved Domains (3) summary
    pfam07496
    Location:338375
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:698790
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:156
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  3. NM_015358.3NP_056173.1  MORC family CW-type zinc finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_056173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC094779, D50926, DA702537
    Consensus CDS
    CCDS42924.1
    UniProtKB/Swiss-Prot
    Q14149
    UniProtKB/TrEMBL
    Q4VBZ9
    Related
    ENSP00000383333.1, ENST00000400485.6
    Conserved Domains (3) summary
    pfam07496
    Location:409446
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:769861
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:29127
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    36320189..36376646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028312.1XP_016883801.1  MORC family CW-type zinc finger protein 3 isoform X2

  2. XM_011529518.2XP_011527820.1  MORC family CW-type zinc finger protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011527820.1

    UniProtKB/TrEMBL
    B4DHJ4
    Conserved Domains (3) summary
    pfam07496
    Location:338375
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:698790
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:156
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  3. XM_017028311.1XP_016883800.1  MORC family CW-type zinc finger protein 3 isoform X1

    UniProtKB/TrEMBL
    B4DHJ4
    Conserved Domains (3) summary
    pfam07496
    Location:338375
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:698790
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:156
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
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