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KCTD2 potassium channel tetramerization domain containing 2 [ Homo sapiens (human) ]

Gene ID: 23510, updated on 12-Oct-2019

Summary

Official Symbol
KCTD2provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 2provided by HGNC
Primary source
HGNC:HGNC:21294
See related
Ensembl:ENSG00000180901 MIM:613422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 22.9), brain (RPKM 16.4) and 24 other tissues See more
Orthologs

Genomic context

See KCTD2 in Genome Data Viewer
Location:
17q25.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75032571..75065886)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73043279..73061981)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L58 Neighboring gene RNA, U6 small nuclear 362, pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 1-1 Neighboring gene tRNA-Arg (anticodon CCT) 2-1 Neighboring gene tRNA-Arg (anticodon TCG) 3-1 Neighboring gene RNA, 7SL, cytoplasmic 573, pseudogene Neighboring gene ATP synthase peripheral stalk subunit d Neighboring gene Sharpr-MPRA regulatory region 3986 Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene solute carrier family 16 member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18320, KIAA0176

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD2
Names
potassium channel tetramerisation domain containing 2
potassium channel tetramerization domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015353.3NP_056168.1  BTB/POZ domain-containing protein KCTD2

    See identical proteins and their annotated locations for NP_056168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the protein.
    Source sequence(s)
    BC033329, CD742648, D79998, DB460074
    Consensus CDS
    CCDS32728.1
    UniProtKB/Swiss-Prot
    Q14681
    UniProtKB/TrEMBL
    Q8IYY2
    Related
    ENSP00000312814.6, ENST00000322444.7
    Conserved Domains (1) summary
    pfam02214
    Location:74163
    BTB_2; BTB/POZ domain

RNA

  1. NR_110834.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the in-frame ORF does not meet RefSeq quality criteria.
    Source sequence(s)
    AC087651, BC033329, CD742648
    Related
    ENST00000375286.7
  2. NR_110835.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains three alternate 5' exons, compared to variant 1. This variant is represented as non-coding because the in-frame ORF does not meet RefSeq quality criteria.
    Source sequence(s)
    AK307083, BC033329, CD742648, DA408645

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75032571..75065886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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