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RIMBP2 RIMS binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23504, updated on 5-Aug-2018

Summary

Official Symbol
RIMBP2provided by HGNC
Official Full Name
RIMS binding protein 2provided by HGNC
Primary source
HGNC:HGNC:30339
See related
Ensembl:ENSG00000060709 MIM:611602; Vega:OTTHUMG00000168385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP2; RIM-BP2; PPP1R133
Expression
Biased expression in brain (RPKM 6.7), adrenal (RPKM 4.2) and 9 other tissues See more
Orthologs

Genomic context

See RIMBP2 in Genome Data Viewer
Location:
12q24.33
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (130396133..130716361, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (130880681..131200828, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984480 Neighboring gene uncharacterized LOC101927786 Neighboring gene piwi like RNA-mediated gene silencing 1 Neighboring gene uncharacterized LOC105370079 Neighboring gene uncharacterized LOC105370080 Neighboring gene uncharacterized LOC107984451

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0318, MGC15831

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RIMS-binding protein 2
Names
RIM binding protein 2
protein phosphatase 1, regulatory subunit 133

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351226.1NP_001338155.1  RIMS-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AC063926, AC073912, AC095350
    Conserved Domains (6) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  2. NM_001351227.1NP_001338156.1  RIMS-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longest isoform (a).
    Source sequence(s)
    AC063926, AC073912, AC095350
    Conserved Domains (6) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  3. NM_001351228.1NP_001338157.1  RIMS-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes the longest isoform (a).
    Source sequence(s)
    AC063926, AC095350
    Conserved Domains (6) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  4. NM_001351229.1NP_001338158.1  RIMS-binding protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC073912, AC095350
    Conserved Domains (6) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  5. NM_001351230.1NP_001338159.1  RIMS-binding protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC073912, AC095350
    Conserved Domains (6) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  6. NM_001351231.1NP_001338160.1  RIMS-binding protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC095350
    Conserved Domains (7) summary
    cd12012
    Location:869930
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9731033
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:317394
    FN3; Fibronectin type 3 domain
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  7. NM_001351232.1NP_001338161.1  RIMS-binding protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC095350
    Related
    ENSP00000496608.1, ENST00000644209.1
    Conserved Domains (4) summary
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:192
    DUF4527; Protein of unknown function (DUF4527)
  8. NM_001351233.1NP_001338162.1  RIMS-binding protein 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC073912, AC095350
    Conserved Domains (4) summary
    cd12014
    Location:79139
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    smart00060
    Location:208285
    FN3; Fibronectin type 3 domain
    cd00063
    Location:395481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:301364
    fn3; Fibronectin type III domain
  9. NM_015347.5NP_056162.4  RIMS-binding protein 2 isoform e

    See identical proteins and their annotated locations for NP_056162.4

    Status: VALIDATED

    Source sequence(s)
    AC063926, AC095350
    Consensus CDS
    CCDS31925.1
    UniProtKB/Swiss-Prot
    O15034
    Related
    ENSP00000261655.4, OTTHUMP00000238667, ENST00000261655.8
    Conserved Domains (5) summary
    cd12012
    Location:852913
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:9561016
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:171231
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:487573
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:393456
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    130396133..130716361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019106.2XP_016874595.1  RIMS-binding protein 2 isoform X5

  2. XM_011538103.3XP_011536405.1  RIMS-binding protein 2 isoform X2

    Conserved Domains (6) summary
    cd12012
    Location:12291290
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:13331393
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:309369
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:625711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:531594
    fn3; Fibronectin type III domain
    cl02488
    Location:50206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_011538105.3XP_011536407.1  RIMS-binding protein 2 isoform X3

    Conserved Domains (6) summary
    cd12012
    Location:9901051
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:10941154
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:309369
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:625711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:531594
    fn3; Fibronectin type III domain
    cl02488
    Location:50206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_011538102.2XP_011536404.1  RIMS-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011536404.1

    Related
    ENSP00000495590.1, ENST00000643940.1
    Conserved Domains (6) summary
    cd12012
    Location:11081169
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12121272
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:197
    DUF4527; Protein of unknown function (DUF4527)
  5. XM_011538104.3XP_011536406.1  RIMS-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011536406.1

    Conserved Domains (6) summary
    cd12012
    Location:11081169
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12121272
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:197
    DUF4527; Protein of unknown function (DUF4527)
  6. XM_011538106.3XP_011536408.1  RIMS-binding protein 2 isoform X4

    Conserved Domains (6) summary
    cd12012
    Location:937998
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:10411101
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:309369
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:625711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:531594
    fn3; Fibronectin type III domain
    cl02488
    Location:50206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_017019105.2XP_016874594.1  RIMS-binding protein 2 isoform X1

    Conserved Domains (6) summary
    cd12012
    Location:11081169
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:12121272
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:188248
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:504590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:410473
    fn3; Fibronectin type III domain
    pfam15030
    Location:197
    DUF4527; Protein of unknown function (DUF4527)
  8. XM_011538107.3XP_011536409.1  RIMS-binding protein 2 isoform X6

    Conserved Domains (4) summary
    cd12014
    Location:309369
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:625711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:531594
    fn3; Fibronectin type III domain
    cl02488
    Location:58206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. XM_011538108.3XP_011536410.1  RIMS-binding protein 2 isoform X7

    Conserved Domains (4) summary
    cd12014
    Location:309369
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:625711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:531594
    fn3; Fibronectin type III domain
    cl02488
    Location:58206
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
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