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ZFYVE26 zinc finger FYVE-type containing 26 [ Homo sapiens (human) ]

Gene ID: 23503, updated on 3-Jun-2018
Official Symbol
ZFYVE26provided by HGNC
Official Full Name
zinc finger FYVE-type containing 26provided by HGNC
Primary source
HGNC:HGNC:20761
See related
Ensembl:ENSG00000072121 MIM:612012; Vega:OTTHUMG00000171274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG15; FYVE-CENT
Summary
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in skin (RPKM 3.6), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
See ZFYVE26 in Genome Data Viewer
Location:
14q24.1
Exon count:
45
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (67728892..67817293, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68213237..68283306, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 213, pseudogene Neighboring gene ribosomal protein L21 pseudogene 9 Neighboring gene retinol dehydrogenase 12 Neighboring gene RAD51 paralog B Neighboring gene centrosomal protein 170kDa pseudogene Neighboring gene uncharacterized LOC105370546 Neighboring gene RNA, 7SL, cytoplasmic 706, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Spastic paraplegia 15
MedGen: C1849128 OMIM: 270700 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0321, DKFZp781H1112, DKFZp686F19106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokinesis IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
zinc finger FYVE domain-containing protein 26
Names
FYVE domain-containing centrosomal protein
spastizin
zinc finger, FYVE domain containing 26

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011836.1 RefSeqGene

    Range
    5001..75070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015346.3NP_056161.2  zinc finger FYVE domain-containing protein 26

    See identical proteins and their annotated locations for NP_056161.2

    Status: REVIEWED

    Source sequence(s)
    AB425197, AK308233, AL049779, BX538025
    Consensus CDS
    CCDS9788.1
    UniProtKB/Swiss-Prot
    Q68DK2
    Related
    ENSP00000251119.5, OTTHUMP00000245710, ENST00000347230.8, OTTHUMT00000412736
    Conserved Domains (1) summary
    cd15724
    Location:18091869
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    67728892..67817293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021125.1XP_016876614.1  zinc finger FYVE domain-containing protein 26 isoform X2

    Related
    ENSP00000450603.1, OTTHUMP00000245713, ENST00000555452.1, OTTHUMT00000412740
  2. XM_017021124.1XP_016876613.1  zinc finger FYVE domain-containing protein 26 isoform X1

  3. XM_017021126.1XP_016876615.1  zinc finger FYVE domain-containing protein 26 isoform X3

  4. XM_017021128.1XP_016876617.1  zinc finger FYVE domain-containing protein 26 isoform X5

  5. XM_017021127.2XP_016876616.1  zinc finger FYVE domain-containing protein 26 isoform X4

  6. XM_011536609.2XP_011534911.1  zinc finger FYVE domain-containing protein 26 isoform X6

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