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Slc36a4 solute carrier family 36 (proton/amino acid symporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 234967, updated on 5-Mar-2024

Summary

Official Symbol
Slc36a4provided by MGI
Official Full Name
solute carrier family 36 (proton/amino acid symporter), member 4provided by MGI
Primary source
MGI:MGI:2442595
See related
Ensembl:ENSMUSG00000043885 AllianceGenome:MGI:2442595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAT4; 6330573I15Rik
Summary
Predicted to enable L-alanine transmembrane transporter activity; L-proline transmembrane transporter activity; and L-tryptophan transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC36A4 (solute carrier family 36 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 9.5), whole brain E14.5 (RPKM 7.8) and 26 other tissues See more
Orthologs
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Genomic context

Location:
9 A2; 9 5.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15621034..15653684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15709738..15742388)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35225 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene melatonin receptor 1B Neighboring gene FAT atypical cadherin 3 Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-proline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables L-tryptophan transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-alanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neutral amino acid uniporter 4
Names
proton-coupled amino acid transporter 4
proton/amino acid transporter 4
solute carrier family 36 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357565.1NP_001344494.1  neutral amino acid uniporter 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC154307, AK150167
    Consensus CDS
    CCDS90503.1
    UniProtKB/TrEMBL
    D3Z0L1
    Related
    ENSMUSP00000111251.2, ENSMUST00000115588.8
    Conserved Domains (1) summary
    cl00456
    Location:54397
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001357566.1NP_001344495.1  neutral amino acid uniporter 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC154307
    Conserved Domains (1) summary
    cl00456
    Location:15337
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001357567.1NP_001344496.1  neutral amino acid uniporter 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (4) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC154307
    Conserved Domains (1) summary
    cl00456
    Location:15265
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_172289.5NP_758493.2  neutral amino acid uniporter 4 isoform 1

    See identical proteins and their annotated locations for NP_758493.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154307, AK032074
    Consensus CDS
    CCDS22840.1
    UniProtKB/Swiss-Prot
    Q8C077, Q8CH36
    UniProtKB/TrEMBL
    A0A0R4J0Q3
    Related
    ENSMUSP00000057355.8, ENSMUST00000061568.9
    Conserved Domains (1) summary
    cl00456
    Location:54469
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15621034..15653684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244281.2XP_030100141.1  neutral amino acid uniporter 4 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:15337
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_006510170.5XP_006510233.1  neutral amino acid uniporter 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8C077, Q8CH36
    Conserved Domains (1) summary
    cl00456
    Location:38453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain