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Med17 mediator complex subunit 17 [ Mus musculus (house mouse) ]

Gene ID: 234959, updated on 30-Apr-2024

Summary

Official Symbol
Med17provided by MGI
Official Full Name
mediator complex subunit 17provided by MGI
Primary source
MGI:MGI:2182585
See related
Ensembl:ENSMUSG00000031935 AllianceGenome:MGI:2182585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
77kDa; Crsp6; Trap80; C330002H14Rik
Summary
Predicted to enable nuclear receptor coactivator activity and thyroid hormone receptor binding activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in female associated reproductive structure; limb mesenchyme; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.0), ovary adult (RPKM 5.5) and 28 other tissues See more
Orthologs
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Genomic context

See Med17 in Genome Data Viewer
Location:
9 A2; 9 4.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15171647..15194576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15260351..15279906, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23370 Neighboring gene predicted gene, 39293 Neighboring gene predicted gene, 51702 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene microRNA 7650

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 17
Names
CRSP complex subunit 6
cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
thyroid hormone receptor-associated protein complex 80 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364533.1NP_001351462.1  mediator of RNA polymerase II transcription subunit 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154296
    Conserved Domains (1) summary
    pfam10156
    Location:123396
    Med17; Subunit 17 of Mediator complex
  2. NM_144933.2NP_659182.1  mediator of RNA polymerase II transcription subunit 17 isoform 1

    See identical proteins and their annotated locations for NP_659182.1

    Status: VALIDATED

    Source sequence(s)
    BC020185, CJ078373
    Consensus CDS
    CCDS22834.1
    UniProtKB/Swiss-Prot
    Q8BYS6, Q8VCD5, Q99KQ1
    Related
    ENSMUSP00000034411.9, ENSMUST00000034411.10
    Conserved Domains (1) summary
    pfam10156
    Location:123396
    Med17; Subunit 17 of Mediator complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15171647..15194576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154859.1XP_036010752.1  mediator of RNA polymerase II transcription subunit 17 isoform X1

    Conserved Domains (1) summary
    pfam10156
    Location:50316
    Med17; Subunit 17 of Mediator complex