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CES3 carboxylesterase 3 [ Homo sapiens (human) ]

Gene ID: 23491, updated on 21-Dec-2019

Summary

Official Symbol
CES3provided by HGNC
Official Full Name
carboxylesterase 3provided by HGNC
Primary source
HGNC:HGNC:1865
See related
Ensembl:ENSG00000172828 MIM:605279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ES31
Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
Expression
Biased expression in colon (RPKM 13.6), duodenum (RPKM 11.5) and 6 other tissues See more
Orthologs

Genomic context

See CES3 in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66961266..66975149)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66995132..67009052)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2 Neighboring gene uncharacterized LOC107984881 Neighboring gene Sharpr-MPRA regulatory region 4953 Neighboring gene carboxylesterase 4A Neighboring gene RNA, 7SL, cytoplasmic 543, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21736

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carboxylic ester hydrolase activity TAS
Traceable Author Statement
more info
 
methyl indole-3-acetate esterase activity IEA
Inferred from Electronic Annotation
more info
 
sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxylesterase 3
Names
carboxylesterase 3 (brain)
esterase 31
liver carboxylesterase 31 homolog
NP_001172105.1
NP_001172106.1
NP_079198.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185176.1NP_001172105.1  carboxylesterase 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons and has an alternate 5' exon, as compared to variant 1. This results in a downstream AUG start codon, and the resulting isoform (3, also known as isoform e) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC009084, AK025158, AK025389, BC053670
    Consensus CDS
    CCDS54023.1
    UniProtKB/Swiss-Prot
    Q6UWW8
    Related
    ENSP00000445559.1, ENST00000543856.1
    Conserved Domains (1) summary
    cl21494
    Location:1186
    Abhydrolase; alpha/beta hydrolases
  2. NM_001185177.2NP_001172106.1  carboxylesterase 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001172106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment in the 3' CDS, as compared to variant 1. The resulting isoform (2, also known as isoform b) lacks an internal three aa, as compared to isoform 1.
    Source sequence(s)
    AK025158, BC053670
    Consensus CDS
    CCDS54022.1
    UniProtKB/Swiss-Prot
    Q6UWW8
    UniProtKB/TrEMBL
    A0A0C4DFY7
    Related
    ENSP00000377602.1, ENST00000394037.5
    Conserved Domains (1) summary
    pfam00135
    Location:32544
    COesterase; Carboxylesterase family
  3. NM_024922.6NP_079198.2  carboxylesterase 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079198.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1, also known as isoform a).
    Source sequence(s)
    AK000105, AK025158, DA924627
    Consensus CDS
    CCDS10826.1
    UniProtKB/Swiss-Prot
    Q6UWW8
    Related
    ENSP00000304782.4, ENST00000303334.9
    Conserved Domains (2) summary
    COG0657
    Location:129247
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:32547
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66961266..66975149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012122.1: Suppressed sequence

    Description
    NM_012122.1: This RefSeq was permanently suppressed because it was based on a sequence from a different organism.
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