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CES3 carboxylesterase 3 [ Homo sapiens (human) ]

Gene ID: 23491, updated on 17-Sep-2024

Summary

Official Symbol
CES3provided by HGNC
Official Full Name
carboxylesterase 3provided by HGNC
Primary source
HGNC:HGNC:1865
See related
Ensembl:ENSG00000172828 MIM:605279; AllianceGenome:HGNC:1865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ES31
Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
Expression
Biased expression in colon (RPKM 13.6), duodenum (RPKM 11.5) and 6 other tissues See more
Orthologs
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Genomic context

See CES3 in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66961266..66975149)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72755566..72769449)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66995169..67009052)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66969029-66969641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66974461-66974960 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:66975020-66976219 Neighboring gene carboxylesterase 2 Neighboring gene uncharacterized LOC107984881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7573 Neighboring gene MPRA-validated peak2620 silencer Neighboring gene MPRA-validated peak2621 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66994865-66995366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66997641-66998558 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:67004920-67006119 Neighboring gene Sharpr-MPRA regulatory region 4953 Neighboring gene Sharpr-MPRA regulatory region 2980 Neighboring gene carboxylesterase 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67034909-67035810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67047193-67047694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67047695-67048194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7575 Neighboring gene RNA, 7SL, cytoplasmic 543, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
carboxylesterase 3
Names
carboxylesterase 3 (brain)
esterase 31
liver carboxylesterase 31 homolog
NP_001172105.1
NP_001172106.1
NP_079198.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185176.2NP_001172105.1  carboxylesterase 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons and has an alternate 5' exon, as compared to variant 1. This results in a downstream AUG start codon, and the resulting isoform (3, also known as isoform e) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC009084, AK025158, AK025389, BC053670
    Consensus CDS
    CCDS54023.1
    UniProtKB/Swiss-Prot
    Q6UWW8
    Related
    ENSP00000445559.1, ENST00000543856.1
    Conserved Domains (1) summary
    cl21494
    Location:1186
    Abhydrolase; alpha/beta hydrolases
  2. NM_001185177.2NP_001172106.1  carboxylesterase 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001172106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment in the 3' CDS, as compared to variant 1. The resulting isoform (2, also known as isoform b) lacks an internal three aa, as compared to isoform 1.
    Source sequence(s)
    AK025158, BC053670
    Consensus CDS
    CCDS54022.1
    UniProtKB/TrEMBL
    A0A0C4DFY7
    Related
    ENSP00000377602.1, ENST00000394037.5
    Conserved Domains (1) summary
    pfam00135
    Location:32544
    COesterase; Carboxylesterase family
  3. NM_024922.6NP_079198.2  carboxylesterase 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_079198.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1, also known as isoform a).
    Source sequence(s)
    AK000105, AK025158, DA924627
    Consensus CDS
    CCDS10826.1
    UniProtKB/Swiss-Prot
    B2Z3W9, F5H242, Q6UWW8, Q7Z6J1, Q9H6X7
    Related
    ENSP00000304782.4, ENST00000303334.9
    Conserved Domains (2) summary
    COG0657
    Location:129247
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:32547
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    66961266..66975149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    72755566..72769449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012122.1: Suppressed sequence

    Description
    NM_012122.1: This RefSeq was permanently suppressed because it was based on a sequence from a different organism.