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Map3k21 mitogen-activated protein kinase kinase kinase 21 [ Mus musculus (house mouse) ]

Gene ID: 234878, updated on 5-Mar-2024

Summary

Official Symbol
Map3k21provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 21provided by MGI
Primary source
MGI:MGI:2385307
See related
Ensembl:ENSMUSG00000031853 AllianceGenome:MGI:2385307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlk4; mKIAA1804
Summary
Predicted to enable JUN kinase kinase kinase activity. Predicted to act upstream of or within phosphorylation. Is expressed in ovary and testis. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 9.7), large intestine adult (RPKM 6.1) and 16 other tissues See more
Orthologs
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Genomic context

Location:
8 E2; 8 73.65 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126637189..126674179)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125910450..125947440)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 2 Neighboring gene predicted gene, 46061 Neighboring gene STARR-seq mESC enhancer starr_23048 Neighboring gene STARR-seq mESC enhancer starr_23049 Neighboring gene RIKEN cDNA A730098A19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:128474175-128474476 Neighboring gene predicted gene, 31069 Neighboring gene predicted gene, 42056

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Clone Names

  • KIAA1804, MGC27778

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 21
Names
mitogen-activated protein kinase kinase kinase MLK4
mixed lineage kinase 4
NP_663583.2
XP_006531034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145608.2NP_663583.2  mitogen-activated protein kinase kinase kinase 21

    See identical proteins and their annotated locations for NP_663583.2

    Status: VALIDATED

    Source sequence(s)
    AC102420, AC105066
    Consensus CDS
    CCDS40519.1
    UniProtKB/Swiss-Prot
    Q5DTU6, Q811F5, Q8VDG6
    Related
    ENSMUSP00000034316.5, ENSMUST00000034316.6
    Conserved Domains (3) summary
    smart00219
    Location:110382
    TyrKc; Tyrosine kinase, catalytic domain
    cl17036
    Location:2882
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:115385
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    126637189..126674179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530971.1XP_006531034.1  mitogen-activated protein kinase kinase kinase 21 isoform X1

    Conserved Domains (1) summary
    TIGR03319
    Location:381
    RNase_Y; ribonuclease Y