Map3k21 mitogen-activated protein kinase kinase kinase 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map3k21provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase 21provided by MGI
Primary source: MGI:MGI:2385307
See related: Ensembl:ENSMUSG00000031853 AllianceGenome:MGI:2385307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mlk4; mKIAA1804
Summary: Predicted to enable JUN kinase kinase kinase activity. Predicted to act upstream of or within phosphorylation. Is expressed in ovary and testis. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 9.7), large intestine adult (RPKM 6.1) and 16 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8; 8 E2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (126637189..126674179)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (125910450..125947440)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MLK4 is a negative regulator of TLR4 signaling.
Title: MLK4 has negative effect on TLR4 signaling.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Homology

Homologs of the Map3k21 gene: The Map3k21 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 330 organisms have orthologs with human gene Map3k21
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 21

Names: mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4

NP_663583.2

EC 2.7.11.25

XP_006531034.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145608.2 → NP_663583.2 mitogen-activated protein kinase kinase kinase 21

See identical proteins and their annotated locations for NP_663583.2

Status: VALIDATED

Source sequence(s)

AC102420, AC105066

Consensus CDS

CCDS40519.1

UniProtKB/Swiss-Prot

Q811F5, Q8VDG6

Related

ENSMUSP00000034316.5, ENSMUST00000034316.6

Conserved Domains (3) summary

smart00219
Location:110 → 382

TyrKc; Tyrosine kinase, catalytic domain

cl17036
Location:28 → 82

SH3; Src Homology 3 domain superfamily

cl21453
Location:115 → 385

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

126637189..126674179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530971.1 → XP_006531034.1 mitogen-activated protein kinase kinase kinase 21 isoform X1

Conserved Domains (1) summary

TIGR03319
Location:3 → 81

RNase_Y; ribonuclease Y