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LEPROTL1 leptin receptor overlapping transcript like 1 [ Homo sapiens (human) ]

Gene ID: 23484, updated on 7-Jun-2020

Summary

Official Symbol
LEPROTL1provided by HGNC
Official Full Name
leptin receptor overlapping transcript like 1provided by HGNC
Primary source
HGNC:HGNC:6555
See related
Ensembl:ENSG00000104660 MIM:607338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Vps55; my047; HSPC112
Expression
Ubiquitous expression in placenta (RPKM 29.1), lymph node (RPKM 17.8) and 24 other tissues See more
Orthologs

Genomic context

See LEPROTL1 in Genome Data Viewer
Location:
8p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30095408..30138348)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29952922..29995222)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1218, pseudogene Neighboring gene store-operated calcium entry associated regulatory factor Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene dynactin subunit 6 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DCTN6

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leptin receptor overlapping transcript-like 1
Names
endospanin-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128208.2NP_001121680.1  leptin receptor overlapping transcript-like 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR, compared to variant 1, resulting in a protein (isoform 2) with a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AC026979, AC044849, DA258969
    Consensus CDS
    CCDS47834.1
    UniProtKB/Swiss-Prot
    O95214
    Related
    ENSP00000428281.1, ENST00000523116.5
    Conserved Domains (1) summary
    pfam04133
    Location:793
    Vps55; Vacuolar protein sorting 55
  2. NM_015344.3NP_056159.2  leptin receptor overlapping transcript-like 1 isoform 1

    See identical proteins and their annotated locations for NP_056159.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC044849
    Consensus CDS
    CCDS6075.1
    UniProtKB/Swiss-Prot
    O95214
    UniProtKB/TrEMBL
    Q6FHL7
    Related
    ENSP00000314625.8, ENST00000321250.13
    Conserved Domains (1) summary
    pfam04133
    Location:7124
    Vps55; Vacuolar protein sorting 55

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30095408..30138348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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