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Rfwd3 ring finger and WD repeat domain 3 [ Mus musculus (house mouse) ]

Gene ID: 234736, updated on 21-Mar-2023

Summary

Official Symbol
Rfwd3provided by MGI
Official Full Name
ring finger and WD repeat domain 3provided by MGI
Primary source
MGI:MGI:2384584
See related
Ensembl:ENSMUSG00000033596 AllianceGenome:MGI:2384584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in chromosome breakage. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 16.9), placenta adult (RPKM 16.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rfwd3 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111997576..112026854, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111270944..111300222, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene predicted gene, 53455 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene mixed lineage kinase domain-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC27888

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RFWD3
Names
RING finger and WD repeat domain-containing protein 3
RING finger protein 201
RING-type E3 ubiquitin transferase RFWD3
NP_666330.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146218.4NP_666330.2  E3 ubiquitin-protein ligase RFWD3

    See identical proteins and their annotated locations for NP_666330.2

    Status: PROVISIONAL

    Source sequence(s)
    AC163625
    Consensus CDS
    CCDS22672.1
    UniProtKB/Swiss-Prot
    Q8CIK8, Q8R351
    Related
    ENSMUSP00000043780.5, ENSMUST00000038739.5
    Conserved Domains (4) summary
    COG2319
    Location:486626
    WD40; WD40 repeat [General function prediction only]
    cd00162
    Location:287334
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    sd00039
    Location:501537
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:451571
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111997576..112026854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)