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TRAM1 translocation associated membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 23471, updated on 1-Jun-2020

Summary

Official Symbol
TRAM1provided by HGNC
Official Full Name
translocation associated membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:20568
See related
Ensembl:ENSG00000067167 MIM:605190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAM; PNAS8; TRAMP
Summary
This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues See more
Orthologs

Genomic context

See TRAM1 in Genome Data Viewer
Location:
8q13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (70573218..70608453, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71485453..71520694, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene ribosomal protein L13 pseudogene 11 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene lactamase beta 2 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • PRO1292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
 
cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
translocating chain-associated membrane protein 1
Names
translocating chain-associating membrane protein
translocation-associating membrane protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317804.2NP_001304733.1  translocating chain-associated membrane protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660, DB448315
    UniProtKB/Swiss-Prot
    Q15629
    Conserved Domains (2) summary
    smart00724
    Location:86295
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:1984
    TRAM1; TRAM1-like protein
  2. NM_001317805.2NP_001304734.1  translocating chain-associated membrane protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660
    Consensus CDS
    CCDS83300.1
    UniProtKB/Swiss-Prot
    Q15629
    UniProtKB/TrEMBL
    G3XAN4
    Related
    ENSP00000428052.1, ENST00000521425.5
    Conserved Domains (2) summary
    smart00724
    Location:31240
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:129
    TRAM1; TRAM1-like protein
  3. NM_014294.6NP_055109.1  translocating chain-associated membrane protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA740941, AC120194, BC037738, BI465346, DB448315
    Consensus CDS
    CCDS6207.1
    UniProtKB/Swiss-Prot
    Q15629
    UniProtKB/TrEMBL
    Q6FHL3
    Related
    ENSP00000262213.2, ENST00000262213.7
    Conserved Domains (2) summary
    smart00724
    Location:117326
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:50115
    TRAM1; TRAM1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    70573218..70608453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013266.1XP_016868755.1  translocating chain-associated membrane protein 1 isoform X1

  2. XM_017013267.2XP_016868756.1  translocating chain-associated membrane protein 1 isoform X1

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