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ICMT isoprenylcysteine carboxyl methyltransferase [ Homo sapiens (human) ]

Gene ID: 23463, updated on 6-Jun-2024

Summary

Official Symbol
ICMTprovided by HGNC
Official Full Name
isoprenylcysteine carboxyl methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:5350
See related
Ensembl:ENSG00000116237 MIM:605851; AllianceGenome:HGNC:5350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCMT; PPMT; PCCMT; HSTE14; MST098; MSTP098
Summary
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 21.7), placenta (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

See ICMT in Genome Data Viewer
Location:
1p36.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6221193..6235964, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5746837..5761608, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6281253..6296024, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 138 Neighboring gene Sharpr-MPRA regulatory region 5942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6265555-6266374 Neighboring gene RNF207 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 139 Neighboring gene Sharpr-MPRA regulatory region 13921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 140 Neighboring gene ring finger protein 207 Neighboring gene MPRA-validated peak28 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6279526-6279711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6296257-6297229 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6299873-6300619 Neighboring gene ICMT divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene hes family bHLH transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC39955

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in C-terminal protein methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in C-terminal protein methylation TAS
Traceable Author Statement
more info
PubMed 
involved_in S-adenosylhomocysteine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in S-adenosylmethioninamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein modification process TAS
Traceable Author Statement
more info
PubMed 
involved_in protein targeting to membrane TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein-S-isoprenylcysteine O-methyltransferase
Names
prenylated protein carboxyl methyltransferase
prenylcysteine carboxyl methyltransferase
NP_036537.1
XP_011539442.1
XP_047272548.1
XP_054191679.1
XP_054191680.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012405.4NP_036537.1  protein-S-isoprenylcysteine O-methyltransferase

    See identical proteins and their annotated locations for NP_036537.1

    Status: REVIEWED

    Source sequence(s)
    AL031847, BC028168, CN343480
    Consensus CDS
    CCDS61.1
    UniProtKB/Swiss-Prot
    O60725, Q6FHT0
    Related
    ENSP00000343552.5, ENST00000343813.10
    Conserved Domains (1) summary
    pfam04140
    Location:164257
    ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6221193..6235964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541140.3XP_011539442.1  protein-S-isoprenylcysteine O-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011539442.1

    UniProtKB/TrEMBL
    B3KS61
    Conserved Domains (1) summary
    pfam04140
    Location:68161
    ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family
  2. XM_047416592.1XP_047272548.1  protein-S-isoprenylcysteine O-methyltransferase isoform X2

    UniProtKB/TrEMBL
    A6NKX2, K7EQW0, Q7Z750
    Related
    ENSP00000466222.1, ENST00000489498.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    5746837..5761608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335704.1XP_054191679.1  protein-S-isoprenylcysteine O-methyltransferase isoform X1

    UniProtKB/TrEMBL
    B3KS61
  2. XM_054335705.1XP_054191680.1  protein-S-isoprenylcysteine O-methyltransferase isoform X2

    UniProtKB/TrEMBL
    A6NKX2, K7EQW0, Q7Z750

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170705.1: Suppressed sequence

    Description
    NM_170705.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.