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ABCB10 ATP binding cassette subfamily B member 10 [ Homo sapiens (human) ]

Gene ID: 23456, updated on 13-May-2022

Summary

Official Symbol
ABCB10provided by HGNC
Official Full Name
ATP binding cassette subfamily B member 10provided by HGNC
Primary source
HGNC:HGNC:41
See related
Ensembl:ENSG00000135776 MIM:605454; AllianceGenome:HGNC:41
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M-ABC2; MTABC2; EST20237
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 17.0), duodenum (RPKM 6.7) and 24 other tissues See more
Orthologs
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Genomic context

See ABCB10 in Genome Data Viewer
Location:
1q42.13
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (229516582..229558707, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (228895342..228937469, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229652329..229694454, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12306 Neighboring gene nucleoporin 133 Neighboring gene Sharpr-MPRA regulatory region 12340 Neighboring gene NUP133 divergent transcript Neighboring gene RNA, U4 small nuclear 21, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 78 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 19 Neighboring gene TATA-box binding protein associated factor 5 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of hemoglobin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family B member 10, mitochondrial
Names
ABC transporter 10 protein
ABC-me protein
ABC-mitochondrial erythroid protein
ATP-binding cassette transporter 10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
mitochondrial ATP-binding cassette 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012089.3NP_036221.2  ATP-binding cassette sub-family B member 10, mitochondrial

    See identical proteins and their annotated locations for NP_036221.2

    Status: REVIEWED

    Source sequence(s)
    AB013380, AF216833, AL121990, BC064930
    Consensus CDS
    CCDS1580.1
    UniProtKB/Swiss-Prot
    Q9NRK6
    Related
    ENSP00000355637.3, ENST00000344517.5
    Conserved Domains (4) summary
    cd03249
    Location:493733
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1132
    Location:163734
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:177438
    ABC_membrane; ABC transporter transmembrane region
    cl02554
    Location:126
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    229516582..229558707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544135.4XP_011542437.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

    Conserved Domains (3) summary
    TIGR02204
    Location:2554
    MsbA_rel; ABC transporter, permease/ATP-binding protein
    cd03249
    Location:314554
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    pfam00664
    Location:1259
    ABC_membrane; ABC transporter transmembrane region
  2. XM_047416589.1XP_047272545.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

  3. XM_011544136.2XP_011542438.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_011542438.1

    Conserved Domains (3) summary
    cd03249
    Location:197437
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1126
    Location:196427
    GlnQ; ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]
    cl00549
    Location:12142
    ABC_membrane; ABC transporter transmembrane region
  4. XM_047416590.1XP_047272546.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    228895342..228937469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)