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ANGPTL2 angiopoietin like 2 [ Homo sapiens (human) ]

Gene ID: 23452, updated on 5-Aug-2018

Summary

Official Symbol
ANGPTL2provided by HGNC
Official Full Name
angiopoietin like 2provided by HGNC
Primary source
HGNC:HGNC:490
See related
Ensembl:ENSG00000136859 MIM:605001; Vega:OTTHUMG00000020695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP2; HARP
Summary
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues See more
Orthologs

Genomic context

See ANGPTL2 in Genome Data Viewer
Location:
9q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (127087349..127122765, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129849628..129885044, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene uncharacterized LOC105376279 Neighboring gene uncharacterized LOC105376278 Neighboring gene GTPase activating Rap/RanGAP domain like 3 Neighboring gene density regulated re-initiation and release factor pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ANGPTL2; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 2
Names
angiopoietin-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012098.2NP_036230.1  angiopoietin-related protein 2 precursor

    See identical proteins and their annotated locations for NP_036230.1

    Status: REVIEWED

    Source sequence(s)
    AK074726, AL598400, BC012368
    Consensus CDS
    CCDS6868.1
    UniProtKB/Swiss-Prot
    Q9UKU9
    UniProtKB/TrEMBL
    A0A024R868
    Related
    ENSP00000362524.3, OTTHUMP00000022159, ENST00000373425.7, OTTHUMT00000054129
    Conserved Domains (1) summary
    cd00087
    Location:273487
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    127087349..127122765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717030.4XP_006717093.1  angiopoietin-related protein 2 isoform X1

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