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ANGPTL2 angiopoietin like 2 [ Homo sapiens (human) ]

Gene ID: 23452, updated on 27-Nov-2024

Summary

Official Symbol
ANGPTL2provided by HGNC
Official Full Name
angiopoietin like 2provided by HGNC
Primary source
HGNC:HGNC:490
See related
Ensembl:ENSG00000136859 MIM:605001; AllianceGenome:HGNC:490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP2; HARP
Summary
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues See more
Orthologs
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Genomic context

See ANGPTL2 in Genome Data Viewer
Location:
9q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127087348..127122635, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139293792..139329078, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129849627..129884914, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129623061-129623858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129630751-129631332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:129645854-129646429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129648667-129649167 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29025 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29031 Neighboring gene uncharacterized LOC105376279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129792702-129793202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129829482-129829982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129874135-129874746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129884227-129884860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129884861-129885494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129885495-129886128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29032 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:129920824-129922023 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:129928436-129929635 Neighboring gene uncharacterized LOC105376278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129943177-129943676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129946409-129946979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129948384-129948884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129957118-129957618 Neighboring gene Sharpr-MPRA regulatory region 1494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129961533-129962521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129969788-129970288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129970289-129970789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129972323-129972840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129974395-129974912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129978722-129979222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129979223-129979723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129981929-129982488 Neighboring gene uncharacterized LOC124902273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129985710-129986210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129986211-129986711

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ANGPTL2; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC8889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 2
Names
angiopoietin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012098.3NP_036230.1  angiopoietin-related protein 2 precursor

    See identical proteins and their annotated locations for NP_036230.1

    Status: REVIEWED

    Source sequence(s)
    AK074726, AL356862, AL598400, BC012368
    Consensus CDS
    CCDS6868.1
    UniProtKB/Swiss-Prot
    Q5JT58, Q8NCH7, Q9UKU9
    UniProtKB/TrEMBL
    B2R780
    Related
    ENSP00000362524.3, ENST00000373425.8
    Conserved Domains (1) summary
    cd00087
    Location:273487
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127087348..127122635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717030.5XP_006717093.1  angiopoietin-related protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139293792..139329078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362559.1XP_054218534.1  angiopoietin-related protein 2 isoform X1