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SLC35A3 solute carrier family 35 member A3 [ Homo sapiens (human) ]

Gene ID: 23443, updated on 25-Jan-2022

Summary

Official Symbol
SLC35A3provided by HGNC
Official Full Name
solute carrier family 35 member A3provided by HGNC
Primary source
HGNC:HGNC:11023
See related
Ensembl:ENSG00000117620 MIM:605632; AllianceGenome:HGNC:11023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMRS
Summary
This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in colon (RPKM 21.3), duodenum (RPKM 16.3) and 24 other tissues See more
Orthologs
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Genomic context

See SLC35A3 in Genome Data Viewer
Location:
1p21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (99968401..100035634)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100435552..100501190)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 9 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Neighboring gene RNA, U6 small nuclear 750, pseudogene Neighboring gene RNA, U6 small nuclear 1318, pseudogene Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene SAS-6 centriolar assembly protein Neighboring gene Sharpr-MPRA regulatory region 13340 Neighboring gene tRNA methyltransferase 13 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781P1297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in UDP-N-acetylglucosamine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in UDP-galactose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-N-acetylglucosamine transporter
Names
golgi UDP-GlcNAc transporter
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033857.1 RefSeqGene

    Range
    5001..62191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271684.2NP_001258613.1  UDP-N-acetylglucosamine transporter isoform 2

    See identical proteins and their annotated locations for NP_001258613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC093019, AC118553, AV698459, BC005136, CR749816
    Consensus CDS
    CCDS60205.1
    UniProtKB/Swiss-Prot
    Q9Y2D2
    Related
    ENSP00000491145.1, ENST00000638336.1
    Conserved Domains (1) summary
    pfam04142
    Location:4220
    Nuc_sug_transp; Nucleotide-sugar transporter
  2. NM_001271685.2NP_001258614.1  UDP-N-acetylglucosamine transporter isoform 3

    See identical proteins and their annotated locations for NP_001258614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure, which introduces an upstream start codon, compared to variant 1. It encodes isoform 3, which has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093019, AC118553, CR749816
    Consensus CDS
    CCDS60204.1
    UniProtKB/Swiss-Prot
    Q9Y2D2
    Related
    ENSP00000359172.1, ENST00000370153.6
    Conserved Domains (2) summary
    TIGR00803
    Location:128354
    nst; UDP-galactose transporter
    pfam04142
    Location:46355
    Nuc_sug_transp; Nucleotide-sugar transporter
  3. NM_012243.3NP_036375.1  UDP-N-acetylglucosamine transporter isoform 1

    See identical proteins and their annotated locations for NP_036375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB021981, AC093019, AC118553, CR749816
    Consensus CDS
    CCDS762.1
    UniProtKB/Swiss-Prot
    Q9Y2D2
    Related
    ENSP00000433849.1, ENST00000533028.8
    Conserved Domains (2) summary
    TIGR00803
    Location:86312
    nst; UDP-galactose transporter
    pfam04142
    Location:4313
    Nuc_sug_transp; Nucleotide-sugar transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    99968401..100035634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270691.5XP_005270748.1  UDP-N-acetylglucosamine transporter isoform X2

    See identical proteins and their annotated locations for XP_005270748.1

    UniProtKB/Swiss-Prot
    Q9Y2D2
    Related
    ENSP00000414947.2, ENST00000427993.7
    Conserved Domains (2) summary
    TIGR00803
    Location:86312
    nst; UDP-galactose transporter
    pfam04142
    Location:4313
    Nuc_sug_transp; Nucleotide-sugar transporter
  2. XM_017000869.2XP_016856358.1  UDP-N-acetylglucosamine transporter isoform X4

    UniProtKB/TrEMBL
    A0A1W2PRT7
    Related
    ENSP00000492771.1, ENST00000640732.1
  3. XM_017000871.2XP_016856360.1  UDP-N-acetylglucosamine transporter isoform X7

    UniProtKB/TrEMBL
    A0A1W2PQL8
    Related
    ENSP00000492169.1, ENST00000639221.1
  4. XM_017000870.2XP_016856359.1  UDP-N-acetylglucosamine transporter isoform X5

    UniProtKB/TrEMBL
    A0A1W2PSD1
    Related
    ENSP00000492801.1, ENST00000640715.1
  5. XM_011541138.3XP_011539440.1  UDP-N-acetylglucosamine transporter isoform X6

    Conserved Domains (1) summary
    cl23754
    Location:128258
    EamA; EamA-like transporter family
  6. XM_011541135.3XP_011539437.1  UDP-N-acetylglucosamine transporter isoform X1

    Conserved Domains (2) summary
    TIGR00803
    Location:128313
    nst; UDP-galactose transporter
    pfam04142
    Location:46314
    Nuc_sug_transp; Nucleotide-sugar transporter
  7. XM_011541137.3XP_011539439.1  UDP-N-acetylglucosamine transporter isoform X3

    Conserved Domains (1) summary
    TIGR00803
    Location:128293
    nst; UDP-galactose transporter
  8. XM_011541136.2XP_011539438.1  UDP-N-acetylglucosamine transporter isoform X2

    See identical proteins and their annotated locations for XP_011539438.1

    UniProtKB/Swiss-Prot
    Q9Y2D2
    Related
    ENSP00000418527.2, ENST00000465289.6
    Conserved Domains (2) summary
    TIGR00803
    Location:86312
    nst; UDP-galactose transporter
    pfam04142
    Location:4313
    Nuc_sug_transp; Nucleotide-sugar transporter
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