Format

Send to:

Choose Destination

OTP orthopedia homeobox [ Homo sapiens (human) ]

Gene ID: 23440, updated on 3-Oct-2020

Summary

Official Symbol
OTPprovided by HGNC
Official Full Name
orthopedia homeoboxprovided by HGNC
Primary source
HGNC:HGNC:8518
See related
Ensembl:ENSG00000171540 MIM:604529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See OTP in Genome Data Viewer
Location:
5q14.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (77628712..77638713, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76924537..76934522, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 41 Neighboring gene ribosomal protein S2 pseudogene 24 Neighboring gene ribosomal protein L7 pseudogene 23 Neighboring gene VISTA enhancer hs262 Neighboring gene tubulin folding cofactor A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
forebrain neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
hypothalamus cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neurohypophysis development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
homeobox protein orthopedia
Names
orthopedia homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032109.3NP_115485.1  homeobox protein orthopedia

    See identical proteins and their annotated locations for NP_115485.1

    Status: REVIEWED

    Source sequence(s)
    AC108173, BC001800
    Consensus CDS
    CCDS4039.1
    UniProtKB/Swiss-Prot
    Q5XKR4
    Related
    ENSP00000302814.3, ENST00000306422.4
    Conserved Domains (2) summary
    pfam00046
    Location:107156
    Homeobox; Homeobox domain
    pfam03826
    Location:302320
    OAR; OAR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    77628712..77638713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center