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Zfp868 zinc finger protein 868 [ Mus musculus (house mouse) ]

Gene ID: 234362, updated on 21-May-2024

Summary

Official Symbol
Zfp868provided by MGI
Official Full Name
zinc finger protein 868provided by MGI
Primary source
MGI:MGI:2142546
See related
Ensembl:ENSMUSG00000060427 AllianceGenome:MGI:2142546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mszf62; C530032E20
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; extraembryonic component; genitourinary system; and limb mesenchyme. Orthologous to human ZNF670 (zinc finger protein 670) and ZNF844 (zinc finger protein 844). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.4), CNS E14 (RPKM 4.1) and 28 other tissues See more
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Genomic context

See Zfp868 in Genome Data Viewer
Location:
8 B3.3; 8 33.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70063305..70078200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69610654..69625557, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21738 Neighboring gene ribosomal protein S7, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_21739 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72085257-72085558 Neighboring gene cadherin 11 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:72095951-72096251 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72098669-72098969 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72103212-72103513 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72105793-72106094 Neighboring gene STARR-positive B cell enhancer ABC_E9116 Neighboring gene STARR-positive B cell enhancer ABC_E453 Neighboring gene STARR-seq mESC enhancer starr_21742 Neighboring gene zinc finger protein 964 Neighboring gene STARR-positive B cell enhancer ABC_E9117 Neighboring gene STARR-positive B cell enhancer ABC_E242 Neighboring gene zinc finger protein 869

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Kruppel-like zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045553.2NP_001039018.1  Kruppel-like zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_001039018.1

    Status: VALIDATED

    Source sequence(s)
    AC157564
    Consensus CDS
    CCDS22347.1
    UniProtKB/TrEMBL
    Q3UTQ6
    Conserved Domains (3) summary
    COG5048
    Location:147398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:324344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1551
    KRAB; KRAB box
  2. NM_001426652.1NP_001413581.1  Kruppel-like zinc finger protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157564
    UniProtKB/TrEMBL
    Q3UTQ6
  3. NM_001426653.1NP_001413582.1  Kruppel-like zinc finger protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157564
    UniProtKB/TrEMBL
    Q3UTQ6
    Related
    ENSMUSP00000074510.7, ENSMUST00000074982.7
  4. NM_001426654.1NP_001413583.1  Kruppel-like zinc finger protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157564
    UniProtKB/TrEMBL
    Q3UTQ6
  5. NM_001426655.1NP_001413584.1  Kruppel-like zinc finger protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157564
  6. NM_172754.3NP_766342.2  Kruppel-like zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_766342.2

    Status: VALIDATED

    Source sequence(s)
    AC157564
    Consensus CDS
    CCDS22347.1
    UniProtKB/TrEMBL
    Q3UTQ6
    Related
    ENSMUSP00000113952.2, ENSMUST00000121886.8
    Conserved Domains (3) summary
    COG5048
    Location:147398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:324344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1551
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70063305..70078200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243459.2XP_030099319.1  Kruppel-like zinc finger protein isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:79330
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256276
    ZF_C2H2; C2H2 Zn finger [structural motif]