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CELA3B chymotrypsin like elastase 3B [ Homo sapiens (human) ]

Gene ID: 23436, updated on 21-Jun-2020

Summary

Official Symbol
CELA3Bprovided by HGNC
Official Full Name
chymotrypsin like elastase 3Bprovided by HGNC
Primary source
HGNC:HGNC:15945
See related
Ensembl:ENSG00000219073 MIM:618694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBPP; ELA3B
Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Expression
Restricted expression toward pancreas (RPKM 10341.0) See more
Orthologs

Genomic context

See CELA3B in Genome Data Viewer
Location:
1p36.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (21977022..21989354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22303418..22315847)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene heparan sulfate proteoglycan 2 Neighboring gene ribosomal protein L21 pseudogene 29 Neighboring gene RNA, U6 small nuclear 1022, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 386, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 186, pseudogene Neighboring gene RNA, U6 small nuclear 776, pseudogene Neighboring gene chymotrypsin like elastase 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chymotrypsin-like elastase family member 3B
Names
cholesterol-binding pancreatic protease
chymotrypsin like elastase family member 3B
elastase 3B, pancreatic
elastase IIIB
elastase-3B
fecal elastase 1
pancreatic elastase 1
pancreatic endopeptidase E
protease E
proteinase E
NP_031378.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007352.4NP_031378.1  chymotrypsin-like elastase family member 3B preproprotein

    See identical proteins and their annotated locations for NP_031378.1

    Status: REVIEWED

    Source sequence(s)
    BC005216, BM128949, BM129235
    Consensus CDS
    CCDS219.1
    UniProtKB/Swiss-Prot
    P08861
    Related
    ENSP00000338369.6, ENST00000337107.11
    Conserved Domains (2) summary
    smart00020
    Location:28263
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29266
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    21977022..21989354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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