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Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 234356, updated on 5-Mar-2024

Summary

Official Symbol
Csgalnact1provided by MGI
Official Full Name
chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by MGI
Primary source
MGI:MGI:2442354
See related
Ensembl:ENSMUSG00000036356 AllianceGenome:MGI:2442354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSGalNAcT-1; 4732435N03Rik
Summary
Predicted to enable hexosyltransferase activity. Acts upstream of or within chondroitin sulfate metabolic process; extracellular matrix organization; and skeletal system development. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.6), frontal lobe adult (RPKM 2.2) and 19 other tissues See more
Orthologs
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Genomic context

Location:
8 B3.3; 8 33.88 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (68809433..69188270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68356781..68735621, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene predicted gene 15991 Neighboring gene STARR-seq mESC enhancer starr_21700 Neighboring gene predicted gene, 22018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70681079-70681379 Neighboring gene STARR-seq mESC enhancer starr_21702 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70772052-70772353 Neighboring gene STARR-seq mESC enhancer starr_21703 Neighboring gene STARR-seq mESC enhancer starr_21704 Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene SH2 domain containing 4A Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene integrator complex subunit 10 Neighboring gene predicted gene, 51577

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Names
beta1,4 N-acetylgalactosaminyltransferase
beta4GalNAcT-1
chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
NP_001239552.1
NP_001351185.1
NP_766341.4
XP_006509689.1
XP_006509690.1
XP_006509691.1
XP_006509692.1
XP_006509693.1
XP_011240592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252623.1NP_001239552.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_001239552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117740, AC123813, AC124427, AC129206, BY289912
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Related
    ENSMUSP00000119817.2, ENSMUST00000130214.8
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. NM_001364256.1NP_001351185.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC117740, AK049770, AK133567
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. NM_172753.5NP_766341.4  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_766341.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117740, AK080687, BY289912
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Related
    ENSMUSP00000077459.7, ENSMUST00000078350.13
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    68809433..69188270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509628.5XP_006509691.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509691.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. XM_006509627.5XP_006509690.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509690.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. XM_011242290.4XP_011240592.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011240592.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  4. XM_006509626.3XP_006509689.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509689.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  5. XM_006509629.2XP_006509692.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509692.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  6. XM_006509630.5XP_006509693.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509693.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_004934803.1 RNA Sequence

  2. XR_004934802.1 RNA Sequence