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RYBP RING1 and YY1 binding protein [ Homo sapiens (human) ]

Gene ID: 23429, updated on 10-Oct-2019

Summary

Official Symbol
RYBPprovided by HGNC
Official Full Name
RING1 and YY1 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:10480
See related
Ensembl:ENSG00000163602 MIM:607535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAP1; DEDAF; YEAF1; APAP-1
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See RYBP in Genome Data Viewer
Location:
3p13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (72374593..72446623, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (72423744..72495774, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377158 Neighboring gene uncharacterized LOC105377159 Neighboring gene uncharacterized LOC105377160 Neighboring gene Sharpr-MPRA regulatory region 11074 Neighboring gene RNA, U1 small nuclear 62, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RING1 and YY1-binding protein
Names
DED-associated factor
YY1 and E4TF1 associated factor 1
apoptin-associating protein 1
death effector domain-associated factor
ring1 interactor RYBP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012234.6NP_036366.3  RING1 and YY1-binding protein

    See identical proteins and their annotated locations for NP_036366.3

    Status: VALIDATED

    Source sequence(s)
    AB029551, AC104330, BC036459, BF939411
    UniProtKB/Swiss-Prot
    Q8N488
    Related
    ENSP00000419494.2, ENST00000477973.3
    Conserved Domains (3) summary
    sd00029
    Location:2544
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:2245
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam17219
    Location:145176
    YAF2_RYBP; Yaf2/RYBP C-terminal binding motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    72374593..72446623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332691.1 Reference GRCh38.p13 PATCHES

    Range
    49167..122044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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