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GRIP1 glutamate receptor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 23426, updated on 21-Apr-2019

Summary

Official Symbol
GRIP1provided by HGNC
Official Full Name
glutamate receptor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:18708
See related
Ensembl:ENSG00000155974 MIM:604597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIP; FRASRS3
Summary
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Annotation information
Note: GRIP1 (Gene ID: 23426) and NCOA2 (Gene ID: 10499) share the GRIP1 symbol/alias in common. GRIP1 is a widely used alternative name for nuclear receptor coactivator 2 (NCOA2), which can be confused with the official symbol for glutamate receptor-interacting protein 1 (GRIP1). [06 Jul 2018]
Expression
Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues See more
Orthologs

Genomic context

See GRIP1 in Genome Data Viewer
Location:
12q14.3
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (66347431..67069265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (66741178..67463014, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 166 Neighboring gene uncharacterized LOC105369811 Neighboring gene DNA helicase B Neighboring gene oxysterol binding protein like 9 pseudogene 4 Neighboring gene oxysterol binding protein like 9 pseudogene 5 Neighboring gene VISTA enhancer hs1498 Neighboring gene uncharacterized LOC102724421 Neighboring gene RAB11A, member RAS oncogene family pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
FRASER SYNDROME 3
MedGen: C4540040 OMIM: 617667 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
beta-catenin binding TAS
Traceable Author Statement
more info
PubMed 
glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
dendrite development IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
vesicle-mediated transport in synapse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021400.2 RefSeqGene

    Range
    395121..726835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178074.1NP_001171545.1  glutamate receptor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001171545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C- termini compared to isoform 1.
    Source sequence(s)
    AC078889, AI190011, AK095519, BC115393, DA801887
    UniProtKB/Swiss-Prot
    Q9Y3R0
    Related
    ENSP00000446047.1, ENST00000538211.5
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001366722.1NP_001353651.1  glutamate receptor-interacting protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC078889, AC090710, AC122686, AC135251
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001366723.1NP_001353652.1  glutamate receptor-interacting protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC078888, AC078889, AC090710, AC135251
    Conserved Domains (1) summary
    cd00992
    Location:178261
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001366724.1NP_001353653.1  glutamate receptor-interacting protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC078888, AC078889, AC090710, AC135251
  5. NM_021150.3NP_066973.2  glutamate receptor-interacting protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC078889, AI190011, BC115393, DA801887
    Consensus CDS
    CCDS41807.1
    UniProtKB/Swiss-Prot
    Q9Y3R0
    Related
    ENSP00000381098.3, ENST00000398016.7
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    66347431..67069265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268757.4XP_005268814.1  glutamate receptor-interacting protein 1 isoform X6

    Related
    ENSP00000439053.1, ENST00000538164.5
    Conserved Domains (1) summary
    cd00992
    Location:126209
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_005268754.4XP_005268811.1  glutamate receptor-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    cd00992
    Location:153236
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_017019101.1XP_016874590.1  glutamate receptor-interacting protein 1 isoform X7

  4. XM_017019099.1XP_016874588.1  glutamate receptor-interacting protein 1 isoform X2

  5. XM_017019102.2XP_016874591.1  glutamate receptor-interacting protein 1 isoform X8

    Conserved Domains (1) summary
    cd00992
    Location:178261
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_011538093.2XP_011536395.1  glutamate receptor-interacting protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q9Y3R0
    Related
    ENSP00000352780.4, ENST00000359742.8
    Conserved Domains (1) summary
    cd00992
    Location:152235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_017019100.1XP_016874589.1  glutamate receptor-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    cd00992
    Location:227310
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_017019098.1XP_016874587.1  glutamate receptor-interacting protein 1 isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:227310
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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