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NOMO1 NODAL modulator 1 [ Homo sapiens (human) ]

Gene ID: 23420, updated on 9-Jun-2020

Summary

Official Symbol
NOMO1provided by HGNC
Official Full Name
NODAL modulator 1provided by HGNC
Primary source
HGNC:HGNC:30060
See related
Ensembl:ENSG00000103512 MIM:609157
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PM5; Nomo
Summary
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 58.5), heart (RPKM 50.3) and 25 other tissues See more
Orthologs

Genomic context

See NOMO1 in Genome Data Viewer
Location:
16p13.11
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (14833721..14896157)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14927643..14990014)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376749 Neighboring gene nuclear pore complex interacting protein family member A2 Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 2 Neighboring gene uncharacterized LOC101927469 Neighboring gene microRNA 3179-1 Neighboring gene microRNA 3670-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
nodal modulator 1
Names
nodal modulator 3
pM5 protein 3
pM5 protein, telomeric copy

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014287.4NP_055102.3  nodal modulator 1 precursor

    See identical proteins and their annotated locations for NP_055102.3

    Status: REVIEWED

    Source sequence(s)
    AC136443, AK125530, BC065535, BI459869, X57398
    Consensus CDS
    CCDS10556.1
    UniProtKB/Swiss-Prot
    Q15155
    Related
    ENSP00000287667.7, ENST00000287667.12
    Conserved Domains (2) summary
    pfam05738
    Location:875927
    Cna_B; Cna protein B-type domain
    pfam13620
    Location:330403
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    14833721..14896157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    890754..953120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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