U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tti2 TELO2 interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 234138, updated on 31-Jan-2023

Summary

Official Symbol
Tti2provided by MGI
Official Full Name
TELO2 interacting protein 2provided by MGI
Primary source
MGI:MGI:2384576
See related
Ensembl:ENSMUSG00000031577 AllianceGenome:MGI:2384576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be part of ASTRA complex. Predicted to be active in centrosome; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TTI2 (TELO2 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.3), CNS E14 (RPKM 4.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tti2 in Genome Data Viewer
Location:
8; 8 A3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31640344..31654731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31150316..31164703)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 122 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene MAK16 homolog Neighboring gene fucosyltransferase 10 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit H pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Clone Names

  • MGC28346

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
part_of ASTRA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TTT complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TELO2-interacting protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199988.1NP_001186917.1  TELO2-interacting protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes a different terminal exon, compared to variant 2. The resulting protein (isoform b) is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC109163, AK084242
    Consensus CDS
    CCDS85525.1
    UniProtKB/TrEMBL
    A0A1B0GSJ1, Q8BNA7
    Related
    ENSMUSP00000147956.2, ENSMUST00000210129.2
    Conserved Domains (1) summary
    pfam10521
    Location:161385
    DUF2454; Protein of unknown function (DUF2454)
  2. NM_144927.3NP_659176.2  TELO2-interacting protein 2 isoform a

    See identical proteins and their annotated locations for NP_659176.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the shorter protein (isoform a).
    Source sequence(s)
    AK045392, AK084242, AW120801
    Consensus CDS
    CCDS22221.1
    UniProtKB/Swiss-Prot
    Q8BGV4, Q8VE31
    UniProtKB/TrEMBL
    Q8BNA7
    Related
    ENSMUSP00000148056.2, ENSMUST00000209851.2
    Conserved Domains (1) summary
    pfam10521
    Location:161385
    DUF2454; Protein of unknown function (DUF2454)

RNA

  1. NR_103719.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs at the 3' end compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109163, AK045392, AK084242, AK139425, AK161965, CJ312549

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    31640344..31654731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001112729.1: Suppressed sequence

    Description
    NM_001112729.1: This RefSeq was permanently suppressed because the transcript is a nonsense-mediated mRNA decay (NMD) candidate when it uses a supported upstream start codon.