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NCS1 neuronal calcium sensor 1 [ Homo sapiens (human) ]

Gene ID: 23413, updated on 10-Dec-2019

Summary

Official Symbol
NCS1provided by HGNC
Official Full Name
neuronal calcium sensor 1provided by HGNC
Primary source
HGNC:HGNC:3953
See related
Ensembl:ENSG00000107130 MIM:603315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLUP; FREQ
Summary
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues See more
Orthologs

Genomic context

See NCS1 in Genome Data Viewer
Location:
9q34.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130172404..130237303)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132934857..132999583)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene formin binding protein 1 Neighboring gene G protein-coupled receptor 107 Neighboring gene GPR107 adjacent cis regulating lncRNA Neighboring gene Sharpr-MPRA regulatory region 4503 Neighboring gene microRNA 12126

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761L1223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
calyx of Held IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dense core granule IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal calcium sensor 1
Names
frequenin homolog
frequenin-like protein
frequenin-like ubiquitous protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128826.2NP_001122298.1  neuronal calcium sensor 1 isoform 2

    See identical proteins and their annotated locations for NP_001122298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AF134479, AI521726, AI564128, AI768193, AL161981, AL360004, BM011362, BQ880305, BU150740, CF453730, CK301145, DA092531
    Consensus CDS
    CCDS78448.1
    UniProtKB/Swiss-Prot
    P62166
    Related
    ENSP00000486695.1, ENST00000630865.1
    Conserved Domains (1) summary
    COG5126
    Location:4161
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_014286.4NP_055101.2  neuronal calcium sensor 1 isoform 1

    See identical proteins and their annotated locations for NP_055101.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF134479, AI521726, AI564128, AI768193, AL161981, AL360004, BC004856, BM011362, BU150740, CF453730, CK301145
    Consensus CDS
    CCDS6932.1
    UniProtKB/Swiss-Prot
    P62166
    UniProtKB/TrEMBL
    A0A024R8B2
    Related
    ENSP00000361475.3, ENST00000372398.6
    Conserved Domains (1) summary
    COG5126
    Location:20179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    130172404..130237303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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