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COMMD3 COMM domain containing 3 [ Homo sapiens (human) ]

Gene ID: 23412, updated on 10-Oct-2019

Summary

Official Symbol
COMMD3provided by HGNC
Official Full Name
COMM domain containing 3provided by HGNC
Primary source
HGNC:HGNC:23332
See related
Ensembl:ENSG00000148444 MIM:616700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BUP; C10orf8
Expression
Ubiquitous expression in heart (RPKM 26.0), appendix (RPKM 25.1) and 25 other tissues See more
Orthologs

Genomic context

See COMMD3 in Genome Data Viewer
Location:
10p12.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (22316388..22320306)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22605312..22609246)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376447 Neighboring gene uncharacterized LOC100130992 Neighboring gene ribosomal protein L31 pseudogene 45 Neighboring gene COMMD3-BMI1 readthrough Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene sperm associated antigen 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough COMMD3-BMI1

Readthrough gene: COMMD3-BMI1, Included gene: BMI1

Homology

Clone Names

  • FLJ45471, DKFZp686K0399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 3
Names
protein Bup

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012071.4NP_036203.1  COMM domain-containing protein 3

    See identical proteins and their annotated locations for NP_036203.1

    Status: VALIDATED

    Source sequence(s)
    AF201948, BF695081
    Consensus CDS
    CCDS7137.1
    UniProtKB/Swiss-Prot
    Q9UBI1
    Related
    ENSP00000366032.3, ENST00000376836.8
    Conserved Domains (1) summary
    cd04751
    Location:98194
    Commd3; COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    22316388..22320306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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