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Arhgef10 Rho guanine nucleotide exchange factor 10 [ Mus musculus (house mouse) ]

Gene ID: 234094, updated on 8-Feb-2024

Summary

Official Symbol
Arhgef10provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 10provided by MGI
Primary source
MGI:MGI:2444453
See related
Ensembl:ENSMUSG00000071176 AllianceGenome:MGI:2444453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0294; 6430549H08Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be located in cytosol. Predicted to be active in centrosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 7.6), bladder adult (RPKM 6.1) and 27 other tissues See more
Orthologs
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Genomic context

See Arhgef10 in Genome Data Viewer
Location:
8 A1.1; 8 7.59 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (14956405..15051085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (14906412..15001085)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DLG associated protein 2 Neighboring gene RIKEN cDNA C030037F17 gene Neighboring gene STARR-seq mESC enhancer starr_20794 Neighboring gene STARR-seq mESC enhancer starr_20795 Neighboring gene STARR-positive B cell enhancer ABC_E4989 Neighboring gene STARR-positive B cell enhancer mm9_chr8:14961480-14961780 Neighboring gene CLN8 transmembrane ER and ERGIC protein Neighboring gene STARR-positive B cell enhancer ABC_E4990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:14996167-14996320 Neighboring gene predicted gene, 35285 Neighboring gene STARR-seq mESC enhancer starr_20800 Neighboring gene predicted gene 16350 Neighboring gene predicted gene, 35149 Neighboring gene kelch repeat and BTB (POZ) domain containing 11 Neighboring gene predicted gene, 35340

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0294

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 10
Names
Rho guanine nucleotide exchange factor (GEF) 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037736.2NP_001032825.1  rho guanine nucleotide exchange factor 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK147669, BC059212, BC066074, CD774578
    Consensus CDS
    CCDS40241.1
    UniProtKB/TrEMBL
    Q3UGZ6
    Related
    ENSMUSP00000106424.3, ENSMUST00000110800.9
    Conserved Domains (2) summary
    pfam00621
    Location:366544
    RhoGEF; RhoGEF domain
    cl17171
    Location:576640
    PH-like; Pleckstrin homology-like domain
  2. NM_172751.3NP_766339.2  rho guanine nucleotide exchange factor 10 isoform a

    See identical proteins and their annotated locations for NP_766339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AK147669, BC059212, BC066074, CD774578
    Consensus CDS
    CCDS40240.1
    UniProtKB/Swiss-Prot
    Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7
    UniProtKB/TrEMBL
    Q3UGZ6
    Related
    ENSMUSP00000081225.6, ENSMUST00000084207.12
    Conserved Domains (3) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8621343
    WD40_2; WD40 repeated domain
    pfam19057
    Location:605754
    PH_19; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    14956405..15051085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243425.2XP_030099285.1  rho guanine nucleotide exchange factor 10 isoform X7

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  2. XM_017312669.3XP_017168158.1  rho guanine nucleotide exchange factor 10 isoform X1

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:482666
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:699763
    PH-like; Pleckstrin homology-like domain
  3. XM_036153887.1XP_036009780.1  rho guanine nucleotide exchange factor 10 isoform X3

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:482666
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:9461427
    WD40_2; WD40 repeated domain
    pfam19057
    Location:689838
    PH_19; PH domain
  4. XM_036153888.1XP_036009781.1  rho guanine nucleotide exchange factor 10 isoform X4

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:443627
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:9071427
    WD40_2; WD40 repeated domain
    pfam19057
    Location:650799
    PH_19; PH domain
  5. XM_036153889.1XP_036009782.1  rho guanine nucleotide exchange factor 10 isoform X6

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:443627
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:9071388
    WD40_2; WD40 repeated domain
    pfam19057
    Location:650799
    PH_19; PH domain
  6. XM_036153886.1XP_036009779.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:481665
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:9451465
    WD40_2; WD40 repeated domain
    pfam19057
    Location:688837
    PH_19; PH domain
  7. XM_017312673.2XP_017168162.1  rho guanine nucleotide exchange factor 10 isoform X7

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  8. XM_006508771.5XP_006508834.1  rho guanine nucleotide exchange factor 10 isoform X7

    See identical proteins and their annotated locations for XP_006508834.1

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  9. XM_036153891.1XP_036009784.1  rho guanine nucleotide exchange factor 10 isoform X10

    UniProtKB/Swiss-Prot
    Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7
    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8621343
    WD40_2; WD40 repeated domain
    pfam19057
    Location:605754
    PH_19; PH domain
  10. XM_006508770.4XP_006508833.1  rho guanine nucleotide exchange factor 10 isoform X7

    See identical proteins and their annotated locations for XP_006508833.1

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:398582
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    PH-like; Pleckstrin homology-like domain
  11. XM_030243426.1XP_030099286.1  rho guanine nucleotide exchange factor 10 isoform X11

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:359543
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:576640
    PH-like; Pleckstrin homology-like domain
  12. XM_006508772.3XP_006508835.1  rho guanine nucleotide exchange factor 10 isoform X8

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:397581
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:614678
    PH-like; Pleckstrin homology-like domain
  13. XM_036153892.1XP_036009785.1  rho guanine nucleotide exchange factor 10 isoform X12

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:397581
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8611342
    WD40_2; WD40 repeated domain
    pfam19057
    Location:604753
    PH_19; PH domain
  14. XM_036153893.1XP_036009786.1  rho guanine nucleotide exchange factor 10 isoform X13

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:358542
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8221342
    WD40_2; WD40 repeated domain
    pfam19057
    Location:565714
    PH_19; PH domain
  15. XM_036153894.1XP_036009787.1  rho guanine nucleotide exchange factor 10 isoform X15

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:358542
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8221303
    WD40_2; WD40 repeated domain
    pfam19057
    Location:565714
    PH_19; PH domain
  16. XM_006508768.4XP_006508831.1  rho guanine nucleotide exchange factor 10 isoform X5

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:422606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:639703
    PH-like; Pleckstrin homology-like domain
  17. XM_017312672.2XP_017168161.1  rho guanine nucleotide exchange factor 10 isoform X14

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (2) summary
    cd00160
    Location:383567
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:600664
    PH-like; Pleckstrin homology-like domain
  18. XM_036153890.1XP_036009783.1  rho guanine nucleotide exchange factor 10 isoform X9

    UniProtKB/TrEMBL
    Q3UGZ6
    Conserved Domains (3) summary
    cd00160
    Location:421605
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam19056
    Location:8851366
    WD40_2; WD40 repeated domain
    pfam19057
    Location:628777
    PH_19; PH domain
  19. XM_006508773.5XP_006508836.1  rho guanine nucleotide exchange factor 10 isoform X16