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SIRT5 sirtuin 5 [ Homo sapiens (human) ]

Gene ID: 23408, updated on 20-Jan-2019

Summary

Official Symbol
SIRT5provided by HGNC
Official Full Name
sirtuin 5provided by HGNC
Primary source
HGNC:HGNC:14933
See related
Ensembl:ENSG00000124523 MIM:604483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L5
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See SIRT5 in Genome Data Viewer
Location:
6p23
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (13574217..13615158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13574506..13615390)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 7 Neighboring gene RNA, 7SK small nuclear pseudogene 204 Neighboring gene uncharacterized LOC105374937 Neighboring gene uncharacterized LOC105374938 Neighboring gene RAN binding protein 9 Neighboring gene nucleolar protein 7 Neighboring gene uncharacterized LOC107986571 Neighboring gene mitochondrial calcium uniporter regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
    NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
  • NAD+ metabolism, organism-specific biosystem (from WikiPathways)
    NAD+ metabolism, organism-specific biosystemNAD+ metabolism in different cellular compartments. The different precursors to intracellular NAD metabolism - tryptophan, nicotinic acid (NA), nicotinamide, NR, and NMN - are shown, along with their...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36950

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine deglutarylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine demalonylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine desuccinylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deglutarylation IDA
Inferred from Direct Assay
more info
PubMed 
protein demalonylation IDA
Inferred from Direct Assay
more info
PubMed 
protein desuccinylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ketone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
silent mating type information regulation 2, S.cerevisiae, homolog 5
sir2-like 5
sirtuin type 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193267.2NP_001180196.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK302467, AL441883, BC000126, CB155518
    Consensus CDS
    CCDS54966.1
    UniProtKB/Swiss-Prot
    Q9NXA8
    Related
    ENSP00000352830.3, ENST00000359782.8
    Conserved Domains (1) summary
    cd01412
    Location:51283
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  2. NM_001242827.1NP_001229756.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_001229756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, resulting in a downstream AUG start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK294162, AL441883, CB155518
    Consensus CDS
    CCDS56398.1
    UniProtKB/Swiss-Prot
    Q9NXA8
    Related
    ENSP00000380509.2, ENST00000397350.6
    Conserved Domains (1) summary
    cl00195
    Location:4193
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. NM_012241.4NP_036373.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_036373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF083110, AL441883, BC000126, DC314190
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    Q9NXA8
    UniProtKB/TrEMBL
    A0A024R012
    Related
    ENSP00000476228.1, ENST00000606117.1
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  4. NM_031244.3NP_112534.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_112534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, C-terminal coding region, and 3' UTR as compared to transcript variant 1. This variant encodes isoform 2 which has a distinct and shorter C-terminus than isoform 1.
    Source sequence(s)
    AJ420496, AK000355, CB155518
    Consensus CDS
    CCDS4527.1
    UniProtKB/Swiss-Prot
    Q9NXA8
    Related
    ENSP00000368564.4, ENST00000379262.8
    Conserved Domains (1) summary
    cd01412
    Location:51285
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    13574217..13615158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010622.2XP_016866111.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd01412
    Location:12262
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  2. XM_005248968.4XP_005249025.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005249025.1

    UniProtKB/Swiss-Prot
    Q9NXA8
    UniProtKB/TrEMBL
    A0A024R012
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  3. XM_017010621.1XP_016866110.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:51183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. XM_024446386.1XP_024302154.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  5. XM_024446387.1XP_024302155.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:51183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  6. XM_024446388.1XP_024302156.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6

    Conserved Domains (1) summary
    cl00195
    Location:51183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  7. XM_017010620.2XP_016866109.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd01412
    Location:51291
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  8. XM_017010624.2XP_016866113.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00195
    Location:51183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  9. XM_011514444.2XP_011512746.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd01412
    Location:12262
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  10. XM_017010623.1XP_016866112.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd01412
    Location:12262
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
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