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Pcid2 PCI domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 234069, updated on 18-Apr-2024

Summary

Official Symbol
Pcid2provided by MGI
Official Full Name
PCI domain containing 2provided by MGI
Primary source
MGI:MGI:2443003
See related
Ensembl:ENSMUSG00000038542 AllianceGenome:MGI:2443003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730042J05Rik
Summary
Predicted to enable RNA binding activity and double-stranded DNA binding activity. Involved in several processes, including positive regulation of B cell differentiation; positive regulation of mitotic cell cycle spindle assembly checkpoint; and spleen development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Is expressed in lung; nervous system; retina layer; and skeletal muscle. Orthologous to human PCID2 (PCI domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.8), thymus adult (RPKM 6.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 A1.1; 8 5.73 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13125476..13155343, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13075476..13105343, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor VII Neighboring gene coagulation factor X Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription initiation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription export complex 2 ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PCI domain-containing protein 2
Names
CSN12-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178708.3NP_848823.2  PCI domain-containing protein 2

    See identical proteins and their annotated locations for NP_848823.2

    Status: VALIDATED

    Source sequence(s)
    AK042945, AK163697, BC118533, BY281425
    Consensus CDS
    CCDS52484.1
    UniProtKB/Swiss-Prot
    Q147Z6, Q8BFV2, Q8C951
    UniProtKB/TrEMBL
    A0JLQ7
    Related
    ENSMUSP00000133204.2, ENSMUST00000164416.8
    Conserved Domains (1) summary
    cl02111
    Location:80393
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13125476..13155343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508761.4XP_006508824.1  PCI domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl02111
    Location:2226
    PCI; PCI domain