Send to:

Choose Destination

COTL1 coactosin like F-actin binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23406, updated on 7-Dec-2018


Official Symbol
COTL1provided by HGNC
Official Full Name
coactosin like F-actin binding protein 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000103187 MIM:606748
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues See more

Genomic context

See COTL1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (84565596..84618096, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84599202..84651669, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 2 Neighboring gene ATP2C2 antisense RNA 1 Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene uncharacterized LOC105371376 Neighboring gene kelch like family member 36 Neighboring gene ubiquitin specific peptidase 10

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ43657, MGC19733

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
enzyme binding IPI
Inferred from Physical Interaction
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
defense response to fungus IEA
Inferred from Electronic Annotation
more info
neutrophil degranulation TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
nucleus IEA
Inferred from Electronic Annotation
more info
secretory granule lumen TAS
Traceable Author Statement
more info

General protein information

Preferred Names
coactosin-like protein
coactosin-like 1
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021149.4NP_066972.1  coactosin-like protein

    See identical proteins and their annotated locations for NP_066972.1

    Status: REVIEWED

    Source sequence(s)
    BC010884, DA968872
    Consensus CDS
    ENSP00000262428.4, ENST00000262428.4
    Conserved Domains (1) summary
    ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    84565596..84618096 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center