ATP13A2 ATPase cation transporting 13A2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATP13A2provided by HGNC
Official Full Name: ATPase cation transporting 13A2provided by HGNC
Primary source: HGNC:HGNC:30213
See related: Ensembl:ENSG00000159363 MIM:610513; AllianceGenome:HGNC:30213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLN12; KRPPD; PARK9; SPG78; HSA9947
Summary: This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Expression: Ubiquitous expression in brain (RPKM 19.6), spleen (RPKM 11.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.13

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (16985958..17011928, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (16796381..16822349, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (17312453..17338423, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H[+],K[+]-ATPase.
Title: Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H(+),K(+)-ATPase.
ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway.
Title: ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway.
Novel mutations in ATP13A2 associated with mixed neurological presentations and iron toxicity due to nonsense-mediated decay.
Title: Novel mutations in ATP13A2 associated with mixed neurological presentations and iron toxicity due to nonsense-mediated decay.
Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Title: Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Title: Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Structural basis of polyamine transport by human ATP13A2 (PARK9).
Title: Structural basis of polyamine transport by human ATP13A2 (PARK9).
Mutation analysis of the ATP13A2 gene in patients with PD and MSA from Italy.
Title: Mutation analysis of the ATP13A2 gene in patients with PD and MSA from Italy.
ATP13A2 Gene Variants in Patients with Parkinson's Disease in Xinjiang.
Title: ATP13A2 Gene Variants in Patients with Parkinson's Disease in Xinjiang.
ATP13A2 Regulates Cellular alpha-Synuclein Multimerization, Membrane Association, and Externalization.
Title: ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization.
Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.
Title: Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal recessive spastic paraplegia type 78 MedGen: C5567893 OMIM: 617225 GeneReviews: Not available	Compare labs
Kufor-Rakeb syndrome MedGen: C1847640 OMIM: 606693 GeneReviews: Parkinson Disease Overview, Neurodegeneration with Brain Iron Accumulation Disorders Overview	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S199 (e-PCR), detects polymorphism
- UniSTS:55297

D1S1592 (e-PCR), detects polymorphism
- UniSTS:55302

NoName (e-PCR)
- UniSTS:28191

GDB:636056 (e-PCR)
- UniSTS:158518

D1S3017 (e-PCR)
- UniSTS:48453

D1S2826 (e-PCR), detects polymorphism
- UniSTS:73656

D1S2644 (e-PCR), detects polymorphism
- UniSTS:71141

Homology

Homologs of the ATP13A2 gene: The ATP13A2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
Orthologs from Annotation Pipeline: 506 organisms have orthologs with human gene ATP13A2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ABC-type polyamine transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	NAS Non-traceable Author Statement more info	PubMed
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATPase-coupled monoatomic cation transmembrane transporter activity	TAS Traceable Author Statement more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cupric ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables polyamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to manganese ion	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to zinc ion	TAS Traceable Author Statement more info	PubMed
involved_in extracellular exosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	TAS Traceable Author Statement more info
involved_in negative regulation of lysosomal protein catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of neuron death	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-aspartic acid autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exosomal secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagosome size	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of autophagosome size	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagy of mitochondrion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of chaperone-mediated autophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucosylceramidase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of lysosomal protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lysosomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macroautophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ubiquitin-specific protease activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal lumen	TAS Traceable Author Statement more info
located_in lysosomal membrane	HDA more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	TAS Traceable Author Statement more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	TAS Traceable Author Statement more info	PubMed
located_in multivesicular body membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyamine-transporting ATPase 13A2

Names: ATPase 13A2; ATPase type 13A2; cation-transporting ATPase 13A2; probable cation-transporting ATPase 13A2

NP_001135445.1

EC 7.2.2.10

NP_001135446.1

EC 7.2.2.10

NP_071372.1

EC 7.2.2.10

XP_005245867.1

EC 7.2.2.10

XP_005245868.1

EC 7.2.2.10

XP_005245869.1

EC 7.2.2.10

XP_005245872.1

EC 7.2.2.10

XP_006710575.1

EC 7.2.2.10

XP_006710576.1

EC 7.2.2.10

XP_011539430.1

EC 7.2.2.10

XP_011539431.1

EC 7.2.2.10

XP_016856333.1

EC 7.2.2.10

XP_016856334.1

EC 7.2.2.10

XP_016856335.1

EC 7.2.2.10

XP_016856336.1

EC 7.2.2.10

XP_016856337.1

EC 7.2.2.10

XP_016856338.1

EC 7.2.2.10

XP_016856339.1

EC 7.2.2.10

XP_047272493.1

EC 7.2.2.10

XP_047272494.1

EC 7.2.2.10

XP_047272495.1

EC 7.2.2.10

XP_047272498.1

EC 7.2.2.10

XP_047272500.1

EC 7.2.2.10

XP_047272502.1

EC 7.2.2.10

XP_047272503.1

EC 7.2.2.10

XP_047272504.1

EC 7.2.2.10

XP_047272505.1

EC 7.2.2.10

XP_047272506.1

EC 7.2.2.10

XP_047272507.1

EC 7.2.2.10

XP_047272509.1

EC 7.2.2.10

XP_047272510.1

EC 7.2.2.10

XP_047272512.1

EC 7.2.2.10

XP_047272516.1

EC 7.2.2.10

XP_047272518.1

EC 7.2.2.10

XP_047272519.1

EC 7.2.2.10

XP_047272520.1

EC 7.2.2.10

XP_047272521.1

EC 7.2.2.10

XP_047272522.1

EC 7.2.2.10

XP_047272523.1

EC 7.2.2.10

XP_047272524.1

EC 7.2.2.10

XP_047272525.1

EC 7.2.2.10

XP_047272526.1

EC 7.2.2.10

XP_047272527.1

EC 7.2.2.10

XP_054188739.1

EC 7.2.2.10

XP_054188740.1

EC 7.2.2.10

XP_054188741.1

EC 7.2.2.10

XP_054188742.1

EC 7.2.2.10

XP_054188743.1

EC 7.2.2.10

XP_054188744.1

EC 7.2.2.10

XP_054188745.1

EC 7.2.2.10

XP_054188746.1

EC 7.2.2.10

XP_054188747.1

EC 7.2.2.10

XP_054188748.1

EC 7.2.2.10

XP_054188749.1

EC 7.2.2.10

XP_054188750.1

EC 7.2.2.10

XP_054188751.1

EC 7.2.2.10

XP_054188752.1

EC 7.2.2.10

XP_054188753.1

EC 7.2.2.10

XP_054188754.1

EC 7.2.2.10

XP_054188755.1

EC 7.2.2.10

XP_054188756.1

EC 7.2.2.10

XP_054188757.1

EC 7.2.2.10

XP_054188758.1

EC 7.2.2.10

XP_054188759.1

EC 7.2.2.10

XP_054188760.1

EC 7.2.2.10

XP_054188761.1

EC 7.2.2.10

XP_054188762.1

EC 7.2.2.10

XP_054188763.1

EC 7.2.2.10

XP_054188764.1

EC 7.2.2.10

XP_054188765.1

EC 7.2.2.10

XP_054188766.1

EC 7.2.2.10

XP_054188767.1

EC 7.2.2.10

XP_054188768.1

EC 7.2.2.10

XP_054188769.1

EC 7.2.2.10

XP_054188770.1

EC 7.2.2.10

XP_054188771.1

EC 7.2.2.10

XP_054188772.1

EC 7.2.2.10

XP_054188773.1

EC 7.2.2.10

XP_054188774.1

EC 7.2.2.10

XP_054188775.1

EC 7.2.2.10

XP_054188776.1

EC 7.2.2.10

XP_054188777.1

EC 7.2.2.10

XP_054188778.1

EC 7.2.2.10

XP_054191604.1

EC 7.2.2.10

XP_054191605.1

EC 7.2.2.10

XP_054191606.1

EC 7.2.2.10

XP_054191607.1

EC 7.2.2.10

XP_054191608.1

EC 7.2.2.10

XP_054191609.1

EC 7.2.2.10

XP_054191610.1

EC 7.2.2.10

XP_054191611.1

EC 7.2.2.10

XP_054191612.1

EC 7.2.2.10

XP_054191613.1

EC 7.2.2.10

XP_054191614.1

EC 7.2.2.10

XP_054191615.1

EC 7.2.2.10

XP_054191616.1

EC 7.2.2.10

XP_054191617.1

EC 7.2.2.10

XP_054191618.1

EC 7.2.2.10

XP_054191619.1

EC 7.2.2.10

XP_054191620.1

EC 7.2.2.10

XP_054191621.1

EC 7.2.2.10

XP_054191622.1

EC 7.2.2.10

XP_054191623.1

EC 7.2.2.10

XP_054191624.1

EC 7.2.2.10

XP_054191625.1

EC 7.2.2.10

XP_054191626.1

EC 7.2.2.10

XP_054191627.1

EC 7.2.2.10

XP_054191628.1

EC 7.2.2.10

XP_054191629.1

EC 7.2.2.10

XP_054191630.1

EC 7.2.2.10

XP_054191631.1

EC 7.2.2.10

XP_054191632.1

EC 7.2.2.10

XP_054191633.1

EC 7.2.2.10

XP_054191634.1

EC 7.2.2.10

XP_054191635.1

EC 7.2.2.10

XP_054191636.1

EC 7.2.2.10

XP_054191637.1

EC 7.2.2.10

XP_054191638.1

EC 7.2.2.10

XP_054191639.1

EC 7.2.2.10

XP_054191640.1

EC 7.2.2.10

XP_054191641.1

EC 7.2.2.10

XP_054191642.1

EC 7.2.2.10

XP_054191643.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009054.1 RefSeqGene

Range

5001..30971

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_834

mRNA and Protein(s)

NM_001141973.3 → NP_001135445.1 polyamine-transporting ATPase 13A2 isoform 2

See identical proteins and their annotated locations for NP_001135445.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). The transcript contains an upstream ORF that could encode a 103aa protein and may modulate translation from the downstream ORF encoding isoform 2.

Source sequence(s)

AK290210, AL354615, BC030267, BC034575

Consensus CDS

CCDS44073.1

UniProtKB/Swiss-Prot

Q9NQ11

UniProtKB/TrEMBL

Q8N4D4

Related

ENSP00000413307.1, ENST00000452699.5

Conserved Domains (1) summary

TIGR01657
Location:39 → 1112

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
NM_001141974.3 → NP_001135446.1 polyamine-transporting ATPase 13A2 isoform 3

See identical proteins and their annotated locations for NP_001135446.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks two alternate exons in the 3' coding region which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1. The transcript contains an upstream ORF that could encode a 103aa protein and may modulate translation from the downstream ORF encoding isoform 3.

Source sequence(s)

AK075310, BC030267, BC034575, HY024349

Consensus CDS

CCDS44072.1

UniProtKB/Swiss-Prot

Q9NQ11

UniProtKB/TrEMBL

Q8N4D4, Q8NBS1

Related

ENSP00000341115.5, ENST00000341676.9

Conserved Domains (5) summary

COG4087
Location:806 → 855

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1034

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:258 → 493

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 169

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:623 → 659

Cation_ATPase; Cation transport ATPase (P-type)
NM_022089.4 → NP_071372.1 polyamine-transporting ATPase 13A2 isoform 1

See identical proteins and their annotated locations for NP_071372.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The transcript contains an upstream ORF that could encode a 103aa protein and may modulate translation from the downstream ORF encoding isoform 1.

Source sequence(s)

AL354615, BC030267, HY024349

Consensus CDS

CCDS175.1

UniProtKB/Swiss-Prot

Q6S9Z9, Q9NQ11

Related

ENSP00000327214.8, ENST00000326735.13

Conserved Domains (5) summary

COG4087
Location:850 → 899

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1117

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:263 → 498

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 174

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:628 → 664

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

16985958..17011928 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047416542.1 → XP_047272498.1 polyamine-transporting ATPase 13A2 isoform X10
XM_047416553.1 → XP_047272509.1 polyamine-transporting ATPase 13A2 isoform X21
XM_047416550.1 → XP_047272506.1 polyamine-transporting ATPase 13A2 isoform X18
XM_047416569.1 → XP_047272525.1 polyamine-transporting ATPase 13A2 isoform X38
XM_006710512.2 → XP_006710575.1 polyamine-transporting ATPase 13A2 isoform X4

Conserved Domains (5) summary

COG4087
Location:844 → 893

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1072

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:257 → 492

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 168

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:622 → 658

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000845.2 → XP_016856334.1 polyamine-transporting ATPase 13A2 isoform X13
XM_047416556.1 → XP_047272512.1 polyamine-transporting ATPase 13A2 isoform X25
XM_047416571.1 → XP_047272527.1 polyamine-transporting ATPase 13A2 isoform X40
XM_006710513.2 → XP_006710576.1 polyamine-transporting ATPase 13A2 isoform X9

Conserved Domains (5) summary

COG4087
Location:836 → 885

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1064

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:249 → 484

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 169

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:614 → 650

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000846.2 → XP_016856335.1 polyamine-transporting ATPase 13A2 isoform X19
XM_047416538.1 → XP_047272494.1 polyamine-transporting ATPase 13A2 isoform X7
XM_047416549.1 → XP_047272505.1 polyamine-transporting ATPase 13A2 isoform X17
XM_047416568.1 → XP_047272524.1 polyamine-transporting ATPase 13A2 isoform X37
XM_017000849.2 → XP_016856338.1 polyamine-transporting ATPase 13A2 isoform X28
XM_005245811.2 → XP_005245868.1 polyamine-transporting ATPase 13A2 isoform X2

Conserved Domains (5) summary

COG4087
Location:845 → 894

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1073

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:258 → 493

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 169

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:623 → 659

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000847.2 → XP_016856336.1 polyamine-transporting ATPase 13A2 isoform X22
XM_047416539.1 → XP_047272495.1 polyamine-transporting ATPase 13A2 isoform X8
XM_047416548.1 → XP_047272504.1 polyamine-transporting ATPase 13A2 isoform X16
XM_047416563.1 → XP_047272519.1 polyamine-transporting ATPase 13A2 isoform X30
XM_047416537.1 → XP_047272493.1 polyamine-transporting ATPase 13A2 isoform X5
XM_047416546.1 → XP_047272502.1 polyamine-transporting ATPase 13A2 isoform X14
XM_047416564.1 → XP_047272520.1 polyamine-transporting ATPase 13A2 isoform X32
XM_047416567.1 → XP_047272523.1 polyamine-transporting ATPase 13A2 isoform X36
XM_047416554.1 → XP_047272510.1 polyamine-transporting ATPase 13A2 isoform X24
XM_047416560.1 → XP_047272516.1 polyamine-transporting ATPase 13A2 isoform X27
XM_005245810.2 → XP_005245867.1 polyamine-transporting ATPase 13A2 isoform X1

Conserved Domains (5) summary

COG4087
Location:849 → 898

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1077

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:262 → 497

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 114

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:627 → 663

Cation_ATPase; Cation transport ATPase (P-type)
XM_047416544.1 → XP_047272500.1 polyamine-transporting ATPase 13A2 isoform X11
XM_047416551.1 → XP_047272507.1 polyamine-transporting ATPase 13A2 isoform X20
XM_047416566.1 → XP_047272522.1 polyamine-transporting ATPase 13A2 isoform X34
XM_047416570.1 → XP_047272526.1 polyamine-transporting ATPase 13A2 isoform X39
XM_047416565.1 → XP_047272521.1 polyamine-transporting ATPase 13A2 isoform X33
XM_005245812.2 → XP_005245869.1 polyamine-transporting ATPase 13A2 isoform X6

Conserved Domains (5) summary

COG4087
Location:841 → 890

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1069

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:254 → 489

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 174

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:619 → 655

Cation_ATPase; Cation transport ATPase (P-type)
XM_047416547.1 → XP_047272503.1 polyamine-transporting ATPase 13A2 isoform X15
XM_047416562.1 → XP_047272518.1 polyamine-transporting ATPase 13A2 isoform X29
XM_011541128.2 → XP_011539430.1 polyamine-transporting ATPase 13A2 isoform X3

Conserved Domains (5) summary

COG4087
Location:845 → 894

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1073

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:263 → 498

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 174

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:623 → 659

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000844.2 → XP_016856333.1 polyamine-transporting ATPase 13A2 isoform X12
XM_011541129.2 → XP_011539431.1 polyamine-transporting ATPase 13A2 isoform X31

Conserved Domains (5) summary

COG4087
Location:781 → 830

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1009

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:263 → 498

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 174

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:559 → 595

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000850.2 → XP_016856339.1 polyamine-transporting ATPase 13A2 isoform X35
XM_005245815.2 → XP_005245872.1 polyamine-transporting ATPase 13A2 isoform X23

Conserved Domains (5) summary

COG4087
Location:811 → 860

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:39 → 1039

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:263 → 498

E1-E2_ATPase; E1-E2 ATPase

pfam12409
Location:39 → 174

P5-ATPase; P5-type ATPase cation transporter

pfam13246
Location:628 → 664

Cation_ATPase; Cation transport ATPase (P-type)
XM_017000848.2 → XP_016856337.1 polyamine-transporting ATPase 13A2 isoform X26