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CTDNEP1 CTD nuclear envelope phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 23399, updated on 7-Jun-2020

Summary

Official Symbol
CTDNEP1provided by HGNC
Official Full Name
CTD nuclear envelope phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:19085
See related
Ensembl:ENSG00000175826 MIM:610684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET56; DULLARD; HSA011916
Expression
Ubiquitous expression in spleen (RPKM 30.6), appendix (RPKM 29.9) and 25 other tissues See more
Orthologs

Genomic context

See CTDNEP1 in Genome Data Viewer
Location:
17p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7243591..7251978, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7146906..7155259, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene solute carrier family 2 member 4 Neighboring gene Y-box binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
gamete generation IEA
Inferred from Electronic Annotation
more info
 
mesoderm development IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
nuclear envelope organization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Nem1-Spo7 phosphatase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CTD nuclear envelope phosphatase 1
Names
C-terminal domain nuclear envelope phosphatase 1
dullard homolog
serine/threonine-protein phosphatase dullard
NP_001137247.1
NP_056158.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143775.2NP_001137247.1  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_001137247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC003688, AC120057, BC009295
    Consensus CDS
    CCDS11093.1
    UniProtKB/Swiss-Prot
    O95476
    Related
    ENSP00000460683.1, ENST00000574322.6
    Conserved Domains (1) summary
    TIGR02251
    Location:61229
    HIF-SF_euk; Dullard-like phosphatase domain
  2. NM_015343.5NP_056158.2  CTD nuclear envelope phosphatase 1

    See identical proteins and their annotated locations for NP_056158.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC003688, AC120057, BC009295
    Consensus CDS
    CCDS11093.1
    UniProtKB/Swiss-Prot
    O95476
    Related
    ENSP00000321732.6, ENST00000318988.10
    Conserved Domains (1) summary
    TIGR02251
    Location:61229
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7243591..7251978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    1354..7306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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