U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fus fused in sarcoma [ Mus musculus (house mouse) ]

Gene ID: 233908, updated on 26-Sep-2022

Summary

Official Symbol
Fusprovided by MGI
Official Full Name
fused in sarcomaprovided by MGI
Primary source
MGI:MGI:1353633
See related
Ensembl:ENSMUSG00000030795 AllianceGenome:MGI:1353633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tls; Fus1; D430004D17Rik; D930039C12Rik
Summary
Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 160.0), CNS E11.5 (RPKM 159.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fus in Genome Data Viewer
Location:
7; 7 F3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127565276..127581204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127966789..127982032)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene protease, serine 8 (prostasin) Neighboring gene protease, serine 36 Neighboring gene predicted gene, 53375 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif-containing 72

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular non-membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of polysome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding protein FUS
Names
fusion, derived from t(12;16) malignant liposarcoma
hnRNP P2
pigpen protein
protein pigpen
translocated in liposarcoma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347649.1NP_001334578.1  RNA-binding protein FUS isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC124461
    Consensus CDS
    CCDS85425.1
    UniProtKB/TrEMBL
    Q8CFQ9
    Related
    ENSMUSP00000076801.6, ENSMUST00000077609.12
  2. NM_139149.2NP_631888.1  RNA-binding protein FUS isoform 1

    See identical proteins and their annotated locations for NP_631888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK139960, AK145582, BY269119
    Consensus CDS
    CCDS21886.1
    UniProtKB/Swiss-Prot
    P56959
    UniProtKB/TrEMBL
    Q3USY4, Q564D0
    Related
    ENSMUSP00000101858.4, ENSMUST00000106251.10
    Conserved Domains (3) summary
    COG0724
    Location:257367
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12535
    Location:276361
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:415442
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127565276..127581204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507760.3XP_006507823.1  RNA-binding protein FUS isoform X1

    Conserved Domains (2) summary
    cd12535
    Location:71156
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:211237
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. XM_017322218.3XP_017177707.1  RNA-binding protein FUS isoform X1

    Conserved Domains (2) summary
    cd12535
    Location:71156
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:211237
    zf-RanBP; Zn-finger in Ran binding protein and others