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ZDHHC17 zinc finger DHHC-type palmitoyltransferase 17 [ Homo sapiens (human) ]

Gene ID: 23390, updated on 7-Jun-2020

Summary

Official Symbol
ZDHHC17provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 17provided by HGNC
Primary source
HGNC:HGNC:18412
See related
Ensembl:ENSG00000186908 MIM:607799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP3; HYPH; HIP14; DHHC-17; HSPC294
Expression
Ubiquitous expression in brain (RPKM 20.0), endometrium (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC17 in Genome Data Viewer
Location:
12q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (76764074..76853701)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77157854..77247481)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 43 Neighboring gene Sharpr-MPRA regulatory region 20 Neighboring gene RWD domain containing 1 pseudogene 3 Neighboring gene cysteine and glycine rich protein 2 Neighboring gene RAN binding protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi-associated vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC17
Names
huntingtin interacting protein 14
huntingtin interacting protein 3
huntingtin yeast partner H
huntingtin-interacting protein H
putative MAPK-activating protein PM11
putative NF-kappa-B-activating protein 205
zinc finger DHHC domain-containing protein 17
zinc finger DHHC-type containing 17
NP_001346555.1
NP_056151.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359626.1NP_001346555.1  palmitoyltransferase ZDHHC17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a shorter 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. This variant intiates transcription from a major transcription start site, as determined by CAGE data. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA843159, AB023163, BC050324, DA803825
    Conserved Domains (3) summary
    cd00204
    Location:77192
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:146177
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:428558
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_015336.3NP_056151.2  palmitoyltransferase ZDHHC17 isoform 1

    See identical proteins and their annotated locations for NP_056151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA843159, AB023163, BC050324, DA227374
    Consensus CDS
    CCDS44946.1
    UniProtKB/Swiss-Prot
    Q8IUH5
    Related
    ENSP00000403397.2, ENST00000426126.6
    Conserved Domains (4) summary
    PHA03095
    Location:100352
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:156187
    ANK; ANK repeat [structural motif]
    pfam01529
    Location:438568
    DHHC; DHHC palmitoyltransferase
    pfam12796
    Location:161255
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    76764074..76853701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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