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FNTA farnesyltransferase, CAAX box, alpha [ Homo sapiens (human) ]

Gene ID: 2339, updated on 7-Jun-2020

Summary

Official Symbol
FNTAprovided by HGNC
Official Full Name
farnesyltransferase, CAAX box, alphaprovided by HGNC
Primary source
HGNC:HGNC:3782
See related
Ensembl:ENSG00000168522 MIM:134635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPTA; PTAR2; PGGT1A
Summary
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in fat (RPKM 32.7), placenta (RPKM 27.4) and 25 other tissues See more
Orthologs

Genomic context

See FNTA in Genome Data Viewer
Location:
8p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (43056299..43085788)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (42911442..42940931)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 170 Neighboring gene microRNA 4469 Neighboring gene hook microtubule tethering protein 3 Neighboring gene RNA, U1 small nuclear 124, pseudogene Neighboring gene protein O-mannose kinase Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene RNY5 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of farnesyltransferase, CAAX box, alpha (FNTA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed
capsid gag Geranylgeranyltransferase-1 modulates both p24CA release and intracellular Gag in TNF-alpha-stimulated U1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
acetylcholine receptor regulator activity IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neurotransmitter receptor metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tubulin deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein farnesylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesylation IDA
Inferred from Direct Assay
more info
PubMed 
protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein geranylgeranylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
skeletal muscle acetylcholine-gated channel clustering IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CAAX-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CAAX-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein farnesyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein farnesyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Names
FTase-alpha
GGTase-I-alpha
farnesyl-protein transferase alpha-subunit
protein prenyltransferase alpha subunit repeat containing 2
ras proteins prenyltransferase subunit alpha
type I protein geranyl-geranyltransferase alpha subunit
NP_002018.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002027.3NP_002018.1  protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

    See identical proteins and their annotated locations for NP_002018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BC084566, BI913631
    Consensus CDS
    CCDS6140.1
    UniProtKB/Swiss-Prot
    P49354
    Related
    ENSP00000303423.3, ENST00000302279.8
    Conserved Domains (1) summary
    cl27590
    Location:64365
    PPTA; Protein prenyltransferase alpha subunit repeat

RNA

  1. NR_033698.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC084566, BI913631, BM686906

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    43056299..43085788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018676.1: Suppressed sequence

    Description
    NM_001018676.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001018677.1: Suppressed sequence

    Description
    NM_001018677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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