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NUDCD3 NudC domain containing 3 [ Homo sapiens (human) ]

Gene ID: 23386, updated on 1-Jun-2020

Summary

Official Symbol
NUDCD3provided by HGNC
Official Full Name
NudC domain containing 3provided by HGNC
Primary source
HGNC:HGNC:22208
See related
Ensembl:ENSG00000015676 MIM:610296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NudCL
Summary
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 28.0), ovary (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See NUDCD3 in Genome Data Viewer
Location:
7p13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44379119..44490875, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44421965..44530474, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene YKT6 v-SNARE homolog Neighboring gene calcium/calmodulin dependent protein kinase II beta Neighboring gene Sharpr-MPRA regulatory region 3634 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene RNA, U6 small nuclear 1097, pseudogene Neighboring gene ribosomal protein L36a pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to pericentriolar material IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nudC domain-containing protein 3
Names
NudC-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015332.4NP_056147.2  nudC domain-containing protein 3

    See identical proteins and their annotated locations for NP_056147.2

    Status: REVIEWED

    Source sequence(s)
    AB028991, AC004453, AW138459, CN386226
    Consensus CDS
    CCDS5490.2
    UniProtKB/Swiss-Prot
    Q8IVD9
    Related
    ENSP00000347626.6, ENST00000355451.8
    Conserved Domains (2) summary
    cd06495
    Location:184285
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
    pfam14050
    Location:967
    Nudc_N; N-terminal conserved domain of Nudc

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44379119..44490875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515247.2XP_011513549.1  nudC domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    cd06495
    Location:184285
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
    pfam14050
    Location:967
    Nudc_N; N-terminal conserved domain of Nudc
  2. XM_017011909.1XP_016867398.1  nudC domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    cd06495
    Location:15116
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
  3. XM_017011910.1XP_016867399.1  nudC domain-containing protein 3 isoform X3

    Conserved Domains (1) summary
    cd06495
    Location:15116
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
  4. XM_017011908.1XP_016867397.1  nudC domain-containing protein 3 isoform X2

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