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Tnrc6a trinucleotide repeat containing 6a [ Mus musculus (house mouse) ]

Gene ID: 233833, updated on 8-Jan-2023

Summary

Official Symbol
Tnrc6aprovided by MGI
Official Full Name
trinucleotide repeat containing 6aprovided by MGI
Primary source
MGI:MGI:2385292
See related
Ensembl:ENSMUSG00000052707 AllianceGenome:MGI:2385292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GW182; Tnrc6; CAGH26; 2010321I05Rik; 3110054G10Rik; D130023A07Rik
Summary
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs
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Genomic context

See Tnrc6a in Genome Data Viewer
Location:
7; 7 F2- F3
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122630324..122794519)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123031101..123195296)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498 Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 11 Neighboring gene Rho GTPase activating protein 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11932

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
trinucleotide repeat-containing gene 6A protein
Names
GW182 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144925.3NP_659174.3  trinucleotide repeat-containing gene 6A protein

    Status: VALIDATED

    Source sequence(s)
    AC138364, AK147327, BF020619, BY720212, CD802917
    Consensus CDS
    CCDS57583.1
    UniProtKB/Swiss-Prot
    F6ZMJ4, Q3UHK8
    Related
    ENSMUSP00000091595.6, ENSMUST00000094053.7
    Conserved Domains (4) summary
    cd12711
    Location:17151797
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10601185
    Ago_hook; Argonaute hook
    pfam12938
    Location:12661416
    M_domain; M domain of GW182
    pfam16608
    Location:14391702
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    122630324..122794519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241757.1XP_011240059.1  trinucleotide repeat-containing gene 6A protein isoform X1

    Conserved Domains (4) summary
    cd12711
    Location:17731855
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12891474
    M_domain; M domain of GW182
    pfam16608
    Location:14971760
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  2. XM_017322202.1XP_017177691.1  trinucleotide repeat-containing gene 6A protein isoform X6

    Conserved Domains (4) summary
    cd12711
    Location:17731855
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12891474
    M_domain; M domain of GW182
    pfam16608
    Location:14971760
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  3. XM_011241760.2XP_011240062.1  trinucleotide repeat-containing gene 6A protein isoform X5

    Conserved Domains (4) summary
    cd12711
    Location:17501832
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12891378
    M_domain; M domain of GW182
    pfam16608
    Location:14741737
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  4. XM_011241762.2XP_011240064.1  trinucleotide repeat-containing gene 6A protein isoform X7

    Conserved Domains (4) summary
    cd12711
    Location:17241806
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12751425
    M_domain; M domain of GW182
    pfam16608
    Location:14481711
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  5. XM_017322203.2XP_017177692.1  trinucleotide repeat-containing gene 6A protein isoform X10

    Conserved Domains (4) summary
    cd12711
    Location:17011783
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12751329
    M_domain; M domain of GW182
    pfam16608
    Location:14251688
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  6. XM_011241758.2XP_011240060.1  trinucleotide repeat-containing gene 6A protein isoform X3

    Conserved Domains (4) summary
    cd12711
    Location:17621844
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691183
    Ago_hook; Argonaute hook
    pfam12938
    Location:12781463
    M_domain; M domain of GW182
    pfam16608
    Location:14861749
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  7. XM_011241763.2XP_011240065.1  trinucleotide repeat-containing gene 6A protein isoform X9

    Conserved Domains (4) summary
    cd12711
    Location:17131795
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10691183
    Ago_hook; Argonaute hook
    pfam12938
    Location:12641414
    M_domain; M domain of GW182
    pfam16608
    Location:14371700
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  8. XM_036153008.1XP_036008901.1  trinucleotide repeat-containing gene 6A protein isoform X12

    Conserved Domains (5) summary
    pfam10427
    Location:10691183
    Ago_hook; Argonaute hook
    pfam12938
    Location:12641318
    M_domain; M domain of GW182
    pfam16608
    Location:14161677
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:16851776
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:596854
    ser_rich_anae_1; serine-rich protein
  9. XM_011241764.2XP_011240066.1  trinucleotide repeat-containing gene 6A protein isoform X15

    Conserved Domains (2) summary
    pfam10427
    Location:10691194
    Ago_hook; Argonaute hook
    pfam12938
    Location:12891361
    M_domain; M domain of GW182
  10. XM_011241765.3XP_011240067.1  trinucleotide repeat-containing gene 6A protein isoform X16

    Conserved Domains (1) summary
    pfam10427
    Location:10691161
    Ago_hook; Argonaute hook
  11. XM_006507705.3XP_006507768.1  trinucleotide repeat-containing gene 6A protein isoform X2

    Conserved Domains (4) summary
    cd12711
    Location:17641846
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10601185
    Ago_hook; Argonaute hook
    pfam12938
    Location:12801465
    M_domain; M domain of GW182
    pfam16608
    Location:14881751
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  12. XM_017322204.3XP_017177693.1  trinucleotide repeat-containing gene 6A protein isoform X11

    Conserved Domains (4) summary
    cd12711
    Location:16921774
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10601185
    Ago_hook; Argonaute hook
    pfam12938
    Location:12661320
    M_domain; M domain of GW182
    pfam16608
    Location:14161679
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  13. XM_017322201.3XP_017177690.1  trinucleotide repeat-containing gene 6A protein isoform X4

    Conserved Domains (4) summary
    cd12711
    Location:17531835
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:10601174
    Ago_hook; Argonaute hook
    pfam12938
    Location:12691454
    M_domain; M domain of GW182
    pfam16608
    Location:14771740
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  14. XM_017322205.3XP_017177694.1  trinucleotide repeat-containing gene 6A protein isoform X13

    Conserved Domains (4) summary
    cd12711
    Location:15091591
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:805930
    Ago_hook; Argonaute hook
    pfam12938
    Location:10251210
    M_domain; M domain of GW182
    pfam16608
    Location:12331496
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  15. XM_036153009.1XP_036008902.1  trinucleotide repeat-containing gene 6A protein isoform X14

    Conserved Domains (5) summary
    pfam10427
    Location:805930
    Ago_hook; Argonaute hook
    pfam12938
    Location:10111161
    M_domain; M domain of GW182
    pfam16608
    Location:11861447
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:14551546
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:332590
    ser_rich_anae_1; serine-rich protein
  16. XM_017322206.3XP_017177695.1  trinucleotide repeat-containing gene 6A protein isoform X13

    Related
    ENSMUSP00000146266.2, ENSMUST00000205760.2
    Conserved Domains (4) summary
    cd12711
    Location:15091591
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:805930
    Ago_hook; Argonaute hook
    pfam12938
    Location:10251210
    M_domain; M domain of GW182
    pfam16608
    Location:12331496
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
  17. XM_036153010.1XP_036008903.1  trinucleotide repeat-containing gene 6A protein isoform X14

    Conserved Domains (5) summary
    pfam10427
    Location:805930
    Ago_hook; Argonaute hook
    pfam12938
    Location:10111161
    M_domain; M domain of GW182
    pfam16608
    Location:11861447
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:14551546
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:332590
    ser_rich_anae_1; serine-rich protein
  18. XM_036153007.1XP_036008900.1  trinucleotide repeat-containing gene 6A protein isoform X8

    Conserved Domains (5) summary
    pfam10427
    Location:10161141
    Ago_hook; Argonaute hook
    pfam12938
    Location:12361421
    M_domain; M domain of GW182
    pfam16608
    Location:14461707
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:17151806
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:543801
    ser_rich_anae_1; serine-rich protein