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Dcun1d3 defective in cullin neddylation 1 domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 233805, updated on 5-Mar-2024

Summary

Official Symbol
Dcun1d3provided by MGI
Official Full Name
defective in cullin neddylation 1 domain containing 3provided by MGI
Primary source
MGI:MGI:2679003
See related
Ensembl:ENSMUSG00000048787 AllianceGenome:MGI:2679003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCNL3; SCCRO3; 1700020A13Rik
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including protein neddylation; regulation of protein modification by small protein conjugation or removal; and response to UV-C. Predicted to be located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Is expressed in genitourinary system. Orthologous to human DCUN1D3 (defective in cullin neddylation 1 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.8), bladder adult (RPKM 2.7) and 26 other tissues See more
Orthologs
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Genomic context

Location:
7 F2; 7 64.27 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119452381..119495553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119853158..119896330, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57786 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369 Neighboring gene predicted gene, 25217

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC40975

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-C ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
DCN1-like protein 3
Names
DCN1, defective in cullin neddylation 1, domain containing 3
DCUN1 domain-containing protein 3
defective in cullin neddylation protein 1-like protein 3
squamous cell carcinoma-related oncogene 3
NP_001157175.1
NP_775584.1
XP_006507744.1
XP_011240050.1
XP_011240051.1
XP_011240053.1
XP_036008898.1
XP_036008899.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163703.1NP_001157175.1  DCN1-like protein 3

    See identical proteins and their annotated locations for NP_001157175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122423, AC131702
    Consensus CDS
    CCDS21789.1
    UniProtKB/Swiss-Prot
    Q8K0V2
    Related
    ENSMUSP00000058968.7, ENSMUST00000059851.14
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  2. NM_173408.3NP_775584.1  DCN1-like protein 3

    See identical proteins and their annotated locations for NP_775584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122423, AC131702
    Consensus CDS
    CCDS21789.1
    UniProtKB/Swiss-Prot
    Q8K0V2
    Related
    ENSMUSP00000095686.3, ENSMUST00000098080.9
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119452381..119495553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241751.2XP_011240053.1  DCN1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011240053.1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  2. XM_011241749.2XP_011240051.1  DCN1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011240051.1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Related
    ENSMUSP00000102129.2, ENSMUST00000106519.8
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  3. XM_036153005.1XP_036008898.1  DCN1-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  4. XM_036153006.1XP_036008899.1  DCN1-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  5. XM_011241748.4XP_011240050.1  DCN1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011240050.1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding
  6. XM_006507681.4XP_006507744.1  DCN1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006507744.1

    UniProtKB/Swiss-Prot
    Q8K0V2
    Conserved Domains (1) summary
    pfam03556
    Location:164276
    Cullin_binding; Cullin binding