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ICE1 interactor of little elongation complex ELL subunit 1 [ Homo sapiens (human) ]

Gene ID: 23379, updated on 5-Aug-2022

Summary

Official Symbol
ICE1provided by HGNC
Official Full Name
interactor of little elongation complex ELL subunit 1provided by HGNC
Primary source
HGNC:HGNC:29154
See related
Ensembl:ENSG00000164151 MIM:617958; AllianceGenome:HGNC:29154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0947
Summary
Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 7.5), brain (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See ICE1 in Genome Data Viewer
Location:
5p15.32
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (5422677..5490220)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (5350239..5417793)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (5422790..5490333)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929200 Neighboring gene MT-CO2 pseudogene 30 Neighboring gene MT-CO1 pseudogene 31 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:5598283-5599482 Neighboring gene uncharacterized LOC105374634

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0947, DKFZp781J2344

General protein information

Preferred Names
little elongation complex subunit 1
Names
interactor of little elongator complex ELL subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015325.3NP_056140.1  little elongation complex subunit 1

    See identical proteins and their annotated locations for NP_056140.1

    Status: VALIDATED

    Source sequence(s)
    AB023164, AL832204, CR749441, DA217623
    Consensus CDS
    CCDS47187.1
    UniProtKB/Swiss-Prot
    Q9NTH9, Q9Y2F5
    Related
    ENSP00000296564.7, ENST00000296564.9
    Conserved Domains (1) summary
    cl09810
    Location:27181
    DUF2031; Protein of unknown function (DUF2031)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    5422677..5490220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513999.3XP_011512301.1  little elongation complex subunit 1 isoform X1

    Conserved Domains (1) summary
    cl09810
    Location:27181
    DUF2031; Protein of unknown function (DUF2031)
  2. XM_047417046.1XP_047273002.1  little elongation complex subunit 1 isoform X2

  3. XM_047417047.1XP_047273003.1  little elongation complex subunit 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    5350239..5417793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)